Cell Biology Antibodies 12

Anti-ADRA2B Antibody (CAB8535)

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SKU:
CAB8535
Product Type:
Antibody
Applications:
WB
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ADRA2B Antibody
Antibody SKU:CAB8535
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRA2B (NP_000673.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-87MG, Mouse skeletal muscle, Mouse kidney, Rat liver, Rat kidney
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRA2B (NP_000673.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MDHQ DPYS VQAT AAIA AAIT FLIL FTIF GNAL VILA VLTS RSLR APQN LFLV SLAA ADIL VATL IIPF SLAN ELLG YWYF RRTW CEVY LALD VLFC TSSI
Gene ID:151
Uniprot:P18089
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:49kDa
Observed MW:50kDa
Synonyms:ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, FAME2, alpha-2BAR
Background:This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system.
UniProt Protein Function:ADRA2B: Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine > norepinephrine > epinephrine = oxymetazoline > dopamine > p-tyramine = phenylephrine > serotonin > p-synephrine / p-octopamine. For antagonists, the rank order is yohimbine > chlorpromazine > phentolamine > mianserine > spiperone > prazosin > alprenolol > propanolol > pindolol. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.
UniProt Protein Details:

Protein type:Membrane protein, integral; Receptor, GPCR; Membrane protein, multi-pass; GPCR, family 1

Chromosomal Location of Human Ortholog: 2q11.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:alpha2-adrenergic receptor activity; epinephrine binding; protein binding

Biological Process: activation of protein kinase B; cell-cell signaling; G-protein coupled receptor protein signaling pathway; positive regulation of neuron differentiation

Disease: Epilepsy, Familial Adult Myoclonic, 2

NCBI Summary:This intronless gene encodes a seven-pass transmembrane protein. This protein is a member of a subfamily of G protein-coupled receptors that regulate neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. [provided by RefSeq, Apr 2014]
UniProt Code:P18089
NCBI GenInfo Identifier:613504690
NCBI Gene ID:151
NCBI Accession:P18089.3
UniProt Secondary Accession:P18089,Q4TUH9, Q53RF2, Q9BZK0,
UniProt Related Accession:P18089
Molecular Weight:49,566 Da
NCBI Full Name:Alpha-2B adrenergic receptor
NCBI Synonym Full Names:adrenoceptor alpha 2B
NCBI Official Symbol:ADRA2B  
NCBI Official Synonym Symbols:FAME2; ADRA2L1; ADRARL1; ADRA2RL1; ALPHA2BAR; alpha-2BAR  
NCBI Protein Information:alpha-2B adrenergic receptor
UniProt Protein Name:Alpha-2B adrenergic receptor
UniProt Synonym Protein Names:Alpha-2 adrenergic receptor subtype C2; Alpha-2B adrenoreceptor; Alpha-2B adrenoceptor; Alpha-2BAR
Protein Family:Alpha-2B adrenergic receptor
UniProt Gene Name:ADRA2B  
UniProt Entry Name:ADA2B_HUMAN
Anti-ADRA2B Polyclonal Antibody (CAB8535)Western blot analysis of extracts of various cell lines, using ADRA2B Antibody (CAB8535) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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