Cell Biology Antibodies 8
Anti-ADRA2A Antibody (CAB2809)
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- SKU:
- CAB2809
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADRA2A Antibody |
| Antibody SKU: | CAB2809 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562, Mouse brain, Mouse Spinal cord |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 240-380 of human ADRA2A (NP_000672.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RRTR VPPS RRGP DAVA APPG GTER RPNG LGPE RSAG PGGA EAEP LPTQ LNGA PGEP APAG PRDT DALD LEES SSSD HAER PPGP RRPE RGPR GKGK ARAS QVKP GDSL PRRG PGAT GIGT PAAG PGEE RVGA AKAS RWRG R |
| Gene ID: | 150 |
| Uniprot: | P08913 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 48kDa |
| Observed MW: | 49kDa |
| Synonyms: | ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32 |
| Background: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. |
| UniProt Protein Function: | Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol. |
| NCBI Summary: | Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08913 |
| NCBI GenInfo Identifier: | 1351829 |
| NCBI Gene ID: | 150 |
| NCBI Accession: | P08913.3 |
| UniProt Secondary Accession: | P08913,Q2I8G2, Q2XN99, Q86TH8, Q9BZK1, B0LPF6, |
| UniProt Related Accession: | P08913 |
| Molecular Weight: | 48,957 Da |
| NCBI Full Name: | Alpha-2A adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor alpha 2A |
| NCBI Official Symbol: | ADRA2A |
| NCBI Official Synonym Symbols: | ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR |
| NCBI Protein Information: | alpha-2A adrenergic receptor |
| UniProt Protein Name: | Alpha-2A adrenergic receptor |
| UniProt Synonym Protein Names: | Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR |
| Protein Family: | Alpha-2A adrenergic receptor |
| UniProt Gene Name: | ADRA2A |
| UniProt Entry Name: | ADA2A_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADRA2A antibody (CAB2809) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of C6 cells using ADRA2A Rabbit pAb (CAB2809) at dilution of 1:100. Blue: DAPI for nuclear staining. |
 | Immunofluorescence analysis of HeLa cells using ADRA2A Rabbit pAb (CAB2809) at dilution of 1:100. Blue: DAPI for nuclear staining. |
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