Cell Biology Antibodies 4

Anti-ADRA2A Antibody (CAB13941)

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SKU:
CAB13941
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ADRA2A Antibody
Antibody SKU:CAB13941
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRA2A (NP_000672.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:U-251MG, Mouse brain, Rat brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ADRA2A (NP_000672.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MFRQ EQPL AEGS FAPM GSLQ PDAG NASW NGTE APGG GARA TPYS LQVT LTLV CLAG LLML LTVF GNVL VIIA VFTS RALK APQN LFLV SLAS ADIL VATL
Gene ID:150
Uniprot:P08913
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:48kDa
Observed MW:49kDa
Synonyms:ADRA2A, ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Background:Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences.
UniProt Protein Function:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is oxymetazoline > clonidine > epinephrine > norepinephrine > phenylephrine > dopamine > p-synephrine > p-tyramine > serotonin = p-octopamine. For antagonists, the rank order is yohimbine > phentolamine = mianserine > chlorpromazine = spiperone = prazosin > propanolol > alprenolol = pindolol.
NCBI Summary:Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
UniProt Code:P08913
NCBI GenInfo Identifier:1351829
NCBI Gene ID:150
NCBI Accession:P08913.3
UniProt Secondary Accession:P08913,Q2I8G2, Q2XN99, Q86TH8, Q9BZK1, B0LPF6,
UniProt Related Accession:P08913
Molecular Weight:48,957 Da
NCBI Full Name:Alpha-2A adrenergic receptor
NCBI Synonym Full Names:adrenoceptor alpha 2A
NCBI Official Symbol:ADRA2A  
NCBI Official Synonym Symbols:ADRA2; ADRAR; ZNF32; ADRA2R; ALPHA2AAR  
NCBI Protein Information:alpha-2A adrenergic receptor
UniProt Protein Name:Alpha-2A adrenergic receptor
UniProt Synonym Protein Names:Alpha-2 adrenergic receptor subtype C10; Alpha-2A adrenoreceptor; Alpha-2A adrenoceptor; Alpha-2AAR
Protein Family:Alpha-2A adrenergic receptor
UniProt Gene Name:ADRA2A  
UniProt Entry Name:ADA2A_HUMAN
Anti-ADRA2A Antibody (CAB13941)Western blot analysis of extracts of various cell lines, using ADRA2A antibody (CAB13941) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s.
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