Cell Biology Antibodies 7
Anti-ADRA1D Antibody (CAB16339)
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- SKU:
- CAB16339
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADRA1D Antibody |
| Antibody SKU: | CAB16339 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human ADRA1D (NP_000669.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 450-550 of human ADRA1D (NP_000669.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | APSS GDAP PGAP LALT ALPD PDPE PPGT PEMQ APVA SRRK PPSA FREW RLLG PFRR PTTQ LRAK VSSL SHKI RAGG AQRA EAAC AQRS EVEA VSLG VPHE V |
| Gene ID: | 146 |
| Uniprot: | P25100 |
| Cellular Location: | Cell membrane, Multi-pass membrane protein |
| Calculated MW: | 60kDa |
| Observed MW: | Refer to figures |
| Synonyms: | ADRA1D, ADRA1, ADRA1A, ADRA1R, ALPHA1, DAR, dJ779E11.2 |
| Background: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. |
| UniProt Protein Function: | ADRA1D: This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA1D sub-subfamily. |
| UniProt Protein Details: | Protein type:GPCR, family 1; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 20p13 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:protein binding Biological Process: cell proliferation; cell-cell signaling; DNA metabolic process; elevation of cytosolic calcium ion concentration; G-protein coupled receptor protein signaling pathway; G-protein signaling, coupled to cAMP nucleotide second messenger; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); multicellular organismal development; norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; positive regulation of vasoconstriction |
| NCBI Summary: | Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P25100 |
| NCBI GenInfo Identifier: | 1168243 |
| NCBI Gene ID: | 146 |
| NCBI Accession: | P25100.2 |
| UniProt Secondary Accession: | P25100,Q9NPY0, |
| UniProt Related Accession: | P25100 |
| Molecular Weight: | 60,463 Da |
| NCBI Full Name: | Alpha-1D adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor alpha 1D |
| NCBI Official Symbol: | ADRA1D |
| NCBI Official Synonym Symbols: | DAR; ADRA1; ADRA1A; ADRA1R; ALPHA1; dJ779E11.2 |
| NCBI Protein Information: | alpha-1D adrenergic receptor |
| UniProt Protein Name: | Alpha-1D adrenergic receptor |
| UniProt Synonym Protein Names: | Alpha-1A adrenergic receptor; Alpha-1D adrenoreceptor; Alpha-1D adrenoceptor; Alpha-adrenergic receptor 1a |
| Protein Family: | Alpha-1D adrenergic receptor |
| UniProt Gene Name: | ADRA1D |
| UniProt Entry Name: | ADA1D_HUMAN |
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