Cell Biology Antibodies 3
Anti-ADPRM Antibody (CAB12883)
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- SKU:
- CAB12883
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADPRM Antibody |
| Antibody SKU: | CAB12883 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-342 of human ADPRM (NP_064618.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse lung, Mouse spleen, Rat brain, Rat lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-342 of human ADPRM (NP_064618.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SEPQ FVQF NGGF SQEQ LNWL NEVL TFSD TNQE KVVI VSHL PIYP DASD NVCL AWNY RDAL AVIW SHEC VVCF FAGH THDG GYSE DPFG VYHV NLEG VIET APDS QAFG TVHV YPDK MMLK GRGR VPDR IMNY KKER AFHC |
| Gene ID: | 56985 |
| Uniprot: | Q3LIE5 |
| Cellular Location: | |
| Calculated MW: | 24kDa/39kDa |
| Observed MW: | 39kDa |
| Synonyms: | ADPRM, C17orf48, MDS006, NBLA03831 |
| Background: |
| UniProt Protein Function: | ADPRM: Hydrolyzes ADP-ribose, IDP-ribose, CDP-glycerol, CDP- choline and CDP-ethanolamine, but not other non-reducing ADP- sugars or CDP-glucose. May be involved in immune cell signaling as suggested by the second-messenger role of ADP-ribose, which activates TRPM2 as a mediator of oxidative/nitrosative stress. Belongs to the ADPRibase-Mn family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.6.1.13; EC 3.6.1.16; EC 3.6.1.53; Hydrolase Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: cytosol Molecular Function:ADP-ribose diphosphatase activity |
| UniProt Code: | Q3LIE5 |
| NCBI GenInfo Identifier: | 121942723 |
| NCBI Gene ID: | 56985 |
| NCBI Accession: | Q3LIE5.1 |
| UniProt Secondary Accession: | Q3LIE5,Q9BVD4, Q9NRU8, A8K9B4, D3DTS4, |
| UniProt Related Accession: | Q3LIE5 |
| Molecular Weight: | 40kDa |
| NCBI Full Name: | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase |
| NCBI Synonym Full Names: | ADP-ribose/CDP-alcohol diphosphatase, manganese dependent |
| NCBI Official Symbol: | ADPRM |
| NCBI Official Synonym Symbols: | MDS006; C17orf48; NBLA03831 |
| NCBI Protein Information: | manganese-dependent ADP-ribose/CDP-alcohol diphosphatase |
| UniProt Protein Name: | Manganese-dependent ADP-ribose/CDP-alcohol diphosphatase |
| UniProt Synonym Protein Names: | ADPRibase-Mn; CDP-choline phosphohydrolase |
| UniProt Gene Name: | ADPRM |
 | Western blot analysis of extracts of various cell lines, using ADPRM antibody (CAB12883) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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