Cell Biology Antibodies 11

Anti-ADH1C Antibody (CAB8081)

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SKU:
CAB8081
Product Type:
Antibody
Applications:
WB
Applications:
IHC
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:ADH1C Rabbit Polyclonal Antibody
Antibody SKU:CAB8081
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human ADH1C (NP_000660.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:A-549, HepG2, 293T
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-375 of human ADH1C (NP_000660.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MSTA GKVI KCKA AVLW ELKK PFSI EEVE VAPP KAHE VRIK MVAA GICR SDEH VVSG NLVT PLPV ILGH EAAG IVES VGEG VTTV KPGD KVIP LFTP QCGK CRIC KNPE SNYC LKND LGNP RGTL QDGT RRFT CSGK PIHH FVGV STFS QYTV VDEN AVAK IDAA SPLE KVCL IGCG FSTG YGSA VKVA KVTP GSTC AVFG LGGV GLSV VMGC KAAG AARI IAVD INKD KFAK AKEL GATE CINP QDYK KPIQ EVLK EMTD GGVD FSFE VIGR LDTM MASL LCCH EACG TSVI VGVP PDSQ NLSI NPML LLTG RTWK GAIF GGFK SKES VPKL VADF MAKK FSLD ALIT NILP FEKI NEGF DLLR SGKS IRTV LTF
Gene ID:126
Uniprot:P00326
Cellular Location:Cytoplasm
Calculated MW:39kDa
Observed MW:45kDa
Synonyms:ADH1C, ADH3
Background:This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster.
UniProt Protein Function:ADH1C: class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Amino Acid Metabolism - tyrosine; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Cofactor and Vitamin Metabolism - retinol; EC 1.1.1.1; Lipid Metabolism - fatty acid; Mitochondrial; Oxidoreductase; Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450

Chromosomal Location of Human Ortholog: 4q23

Cellular Component: cytosol; nucleoplasm; plasma membrane

Molecular Function:alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; retinol dehydrogenase activity

Biological Process: ethanol oxidation

Disease: Alcohol Dependence; Parkinson Disease, Late-onset

NCBI Summary:This gene encodes class I alcohol dehydrogenase, gamma subunit, which is a member of the alcohol dehydrogenase family. Members of this enzyme family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. Class I alcohol dehydrogenase, consisting of several homo- and heterodimers of alpha, beta, and gamma subunits, exhibits high activity for ethanol oxidation and plays a major role in ethanol catabolism. Three genes encoding alpha, beta and gamma subunits are tandemly organized in a genomic segment as a gene cluster. [provided by RefSeq, Jul 2008]
UniProt Code:P00326
NCBI GenInfo Identifier:113398
NCBI Gene ID:126
NCBI Accession:P00326.2
UniProt Secondary Accession:P00326,Q4PJ18, Q5WRV0, Q6LBW4, Q6NWV0, Q6NZA7,
UniProt Related Accession:P00326
Molecular Weight:40kDa
NCBI Full Name:Alcohol dehydrogenase 1C
NCBI Synonym Full Names:alcohol dehydrogenase 1C (class I), gamma polypeptide
NCBI Official Symbol:ADH1C  
NCBI Official Synonym Symbols:ADH3  
NCBI Protein Information:alcohol dehydrogenase 1C
UniProt Protein Name:Alcohol dehydrogenase 1C
UniProt Synonym Protein Names:Alcohol dehydrogenase subunit gamma
Protein Family:Alcohol dehydrogenase
UniProt Gene Name:ADH1C  
Anti-ADH1C Polyclonal Antibody (CAB8081)Western blot analysis of extracts of various cell lines, using ADH1C antibody (CAB8081) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25ug per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (RM00021)._Exposure time: 10s.
Anti-ADH1C Polyclonal Antibody (CAB8081)Immunohistochemistry of paraffin-embedded human esophagus using ADH1C antibody (CAB8081) at dilution of 1:100 (40x lens).
Anti-ADH1C Polyclonal Antibody (CAB8081)Immunohistochemistry of paraffin-embedded human stomach using ADH1C antibody (CAB8081) at dilution of 1:100 (40x lens).
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