Cell Biology Antibodies 18
Anti-ADGRG1 Antibody (CAB18403)
- SKU:
- CAB18403
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADGRG1 Antibody |
| Antibody SKU: | CAB18403 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ADGRG1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant protein of human ADGRG1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 9289 |
| Uniprot: | Q9Y653 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | BFPP, BPPR, GPR56, TM7LN4, TM7XN1, ADGRG1 |
| Background: |
| UniProt Protein Function: | GPR56: Could be involved in cell-cell interactions. Defects in GPR56 are the cause of bilateral frontoparietal polymicrogyria (BFPP). BFPP is characterized by disorganized cortical lamination that is most severe in frontal cortex. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:GPCR, family 2; Receptor, GPCR; Membrane protein, integral; Membrane protein, multi-pass; Cell adhesion Chromosomal Location of Human Ortholog: 16q21 Cellular Component: integral to membrane; integral to plasma membrane; intracellular Molecular Function:collagen binding; extracellular matrix binding; G-protein coupled receptor activity Biological Process: angiogenesis; brain development; cell adhesion; cell surface receptor linked signal transduction; cell-cell signaling; cerebral cortex radial glia guided migration; cerebral cortex regionalization; G-protein coupled receptor protein signaling pathway; layer formation in the cerebral cortex; negative regulation of cell proliferation; positive regulation of cell adhesion; positive regulation of Rho protein signal transduction; Rho protein signal transduction Disease: Polymicrogyria, Bilateral Frontoparietal; Polymicrogyria, Bilateral Perisylvian, Autosomal Recessive |
| NCBI Summary: | This gene encodes a member of the G protein-coupled receptor family and regulates brain cortical patterning. The encoded protein binds specifically to transglutaminase 2, a component of tissue and tumor stroma implicated as an inhibitor of tumor progression. Mutations in this gene are associated with a brain malformation known as bilateral frontoparietal polymicrogyria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q9Y653 |
| NCBI GenInfo Identifier: | 45476992 |
| NCBI Gene ID: | 9289 |
| NCBI Accession: | Q9Y653.2 |
| UniProt Secondary Accession: | Q9Y653,O95966, Q6ZMP1, Q8NGB3, Q96HB4, A6NIT7, A6NJV9 B0M0K4, B4DR54, |
| UniProt Related Accession: | Q9Y653 |
| Molecular Weight: | 58,042 Da |
| NCBI Full Name: | G-protein coupled receptor 56 |
| NCBI Synonym Full Names: | adhesion G protein-coupled receptor G1 |
| NCBI Official Symbol: | ADGRG1 |
| NCBI Official Synonym Symbols: | BFPP; BPPR; GPR56; TM7LN4; TM7XN1 |
| NCBI Protein Information: | G-protein coupled receptor 56 |
| UniProt Protein Name: | Adhesion G-protein coupled receptor G1 |
| UniProt Synonym Protein Names: | G-protein coupled receptor 56; Protein TM7XN1 |
| UniProt Gene Name: | ADGRG1 |
| UniProt Entry Name: | AGRG1_HUMAN |
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