Cell Biology Antibodies 18

Anti-ADD3 Antibody (CAB18336)

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SKU:
CAB18336
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ADD3 Antibody
Antibody SKU:CAB18336
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ADD3 (NP_001307523.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 400-500 of human ADD3 (NP_001307523.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:120
Uniprot:Q9UEY8
Cellular Location:
Calculated MW:
Observed MW:Refer to figures
Synonyms:ADDL, CPSQ3, ADD3
Background:
UniProt Protein Function:ADD3: is a heteromeric protein composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. Adducins alpha and gamma are ubiquitously expressed, while the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions of alpha and beta have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described.
UniProt Protein Details:

Protein type:Cytoskeletal; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 10q25.2

Cellular Component: cytoplasm; cytosol; membrane; nucleoplasm; plasma membrane

Molecular Function:structural constituent of cytoskeleton

Biological Process: transmembrane transport

NCBI Summary:Adducins are heteromeric proteins composed of different subunits referred to as adducin alpha, beta and gamma. The three subunits are encoded by distinct genes and belong to a family of membrane skeletal proteins involved in the assembly of spectrin-actin network in erythrocytes and at sites of cell-cell contact in epithelial tissues. While adducins alpha and gamma are ubiquitously expressed, the expression of adducin beta is restricted to brain and hematopoietic tissues. Adducin, originally purified from human erythrocytes, was found to be a heterodimer of adducins alpha and beta. Polymorphisms resulting in amino acid substitutions in these two subunits have been associated with the regulation of blood pressure in an animal model of hypertension. Heterodimers consisting of alpha and gamma subunits have also been described. Structurally, each subunit is comprised of two distinct domains. The amino-terminal region is protease resistant and globular in shape, while the carboxy-terminal region is protease sensitive. The latter contains multiple phosphorylation sites for protein kinase C, the binding site for calmodulin, and is required for association with spectrin and actin. Alternatively spliced adducin gamma transcripts encoding different isoforms have been described. The functions of the different isoforms are not known. [provided by RefSeq, Jul 2008]
UniProt Code:Q9UEY8
NCBI GenInfo Identifier:12643881
NCBI Gene ID:120
NCBI Accession:Q9UEY8.1
UniProt Secondary Accession:Q9UEY8,O43243, Q5VU09, Q92773, Q9UEY7, D3DRA8,
UniProt Related Accession:Q9UEY8
Molecular Weight:75,671 Da
NCBI Full Name:Gamma-adducin
NCBI Synonym Full Names:adducin 3
NCBI Official Symbol:ADD3  
NCBI Official Synonym Symbols:ADDL; CPSQ3  
NCBI Protein Information:gamma-adducin
UniProt Protein Name:Gamma-adducin
UniProt Synonym Protein Names:Adducin-like protein 70
Protein Family:Gamma-adducin
UniProt Gene Name:ADD3  
UniProt Entry Name:ADDG_HUMAN
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