| UniProt Protein Function: | ADCY6: a membrane-associated enzyme that catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). Expressed in normal thyroid and brain tissues, as well as some tumors; its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. Protein type: Nucleotide Metabolism - purine; EC 4.6.1.1; Transporter; Lyase; Adenylyl cyclase; Membrane protein, multi-pass; Transporter, aquaporin family; Membrane protein, integral Chromosomal Location of Human Ortholog: 12q12-q13 Cellular Component: membrane; plasma membrane; integral to membrane; cilium Molecular Function: protein binding; metal ion binding; protein kinase binding; ATP binding; adenylate cyclase activity Biological Process: epidermal growth factor receptor signaling pathway; synaptic transmission; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; phospholipase C activation; water transport; activation of protein kinase A; dopamine receptor signaling pathway; energy reserve metabolic process; innate immune response; renal water homeostasis; cAMP biosynthetic process; G-protein signaling, adenylate cyclase inhibiting pathway; signal transduction; transmembrane transport; G-protein signaling, adenylate cyclase activating pathway Disease: Lethal Congenital Contracture Syndrome 8 |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes adenylate cyclase 6, which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). The expression of this gene is found in normal thyroid and brain tissues, as well as some tumors; and its expression is significantly higher in one hyperfunctioning thyroid tumor than in normal thyroid tissue. Alternative splicing generates 2 transcript variants. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43306 |
| NCBI GenInfo Identifier: | 12644065 |
| NCBI Gene ID: | 112 |
| NCBI Accession: | O43306.2 |
| UniProt Secondary Accession: | O43306,Q9NR75, Q9UDB0 |
| UniProt Related Accession: | O43306 |
| Molecular Weight: | |
| NCBI Full Name: | Adenylate cyclase type 6 |
| NCBI Synonym Full Names: | adenylate cyclase 6 |
| NCBI Official Symbol: | ADCY6 |
| NCBI Official Synonym Symbols: | AC6 |
| NCBI Protein Information: | adenylate cyclase type 6; ATP pyrophosphate-lyase 6; adenylate cyclase type VI; adenylyl cyclase 6; ca(2+)-inhibitable adenylyl cyclase |
| UniProt Protein Name: | Adenylate cyclase type 6 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 6; Adenylate cyclase type VI; Adenylyl cyclase 6; Ca(2+)-inhibitable adenylyl cyclase |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY6 |
| UniProt Entry Name: | ADCY6_HUMAN |
