Description
| Antibody Name: | Anti-ADCY3 Antibody |
| Antibody SKU: | CAB7870 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADCY3 (NP_004027.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | SH-SY5Y, 293T, HepG2, MCF7, Mouse brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADCY3 (NP_004027.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MPRN QGFS EPEY SAEY SAEY SVSL PSDP DRGV GRTH EISV RNSG SCLC LPRF MRLT FVPE SLEN LYQT YFKR QRHE TLLV |
| Gene ID: | 109 |
| Uniprot: | O60266 |
| Cellular Location: | Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Multi-pass membrane protein, cilium |
| Calculated MW: | 82kDa/128kDa |
| Observed MW: | 150-170kDa |
| Synonyms: | ADCY3, AC-III, AC3 |
| Background: | This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| NCBI Summary: | This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016] |
| UniProt Code: | O60266 |
| NCBI GenInfo Identifier: | 1002341785 |
| NCBI Gene ID: | 109 |
| NCBI Accession: | NP_001307542.1 |
| UniProt Secondary Accession: | O60266,Q53T54, Q9UDB1, B3KT86, |
| UniProt Related Accession: | O60266 |
| Molecular Weight: | 129 kDa |
| NCBI Full Name: | adenylate cyclase type 3 isoform 1 |
| NCBI Synonym Full Names: | adenylate cyclase 3 |
| NCBI Official Symbol: | ADCY3 |
| NCBI Official Synonym Symbols: | AC3; AC-III; BMIQ19 |
| NCBI Protein Information: | adenylate cyclase type 3 |
| UniProt Protein Name: | Adenylate cyclase type 3 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3 |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY3 |
 | Western blot analysis of extracts of various cell lines, using ADCY3 antibody (CAB7870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s. |
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