Metabolism Antibodies 2

Anti-ADCY3 Antibody (CAB7870)

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SKU:
CAB7870
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ADCY3 Antibody
Antibody SKU:CAB7870
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADCY3 (NP_004027.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:1000
Reactivity:Human, Mouse
Positive Samples:SH-SY5Y, 293T, HepG2, MCF7, Mouse brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human ADCY3 (NP_004027.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPRN QGFS EPEY SAEY SAEY SVSL PSDP DRGV GRTH EISV RNSG SCLC LPRF MRLT FVPE SLEN LYQT YFKR QRHE TLLV
Gene ID:109
Uniprot:O60266
Cellular Location:Cell membrane, Cell projection, Cytoplasm, Golgi apparatus, Multi-pass membrane protein, cilium
Calculated MW:82kDa/128kDa
Observed MW:150-170kDa
Synonyms:ADCY3, AC-III, AC3
Background:This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
NCBI Summary:This gene encodes adenylyl cyclase 3 which is a membrane-associated enzyme and catalyzes the formation of the secondary messenger cyclic adenosine monophosphate (cAMP). This protein appears to be widely expressed in various human tissues and may be involved in a number of physiological and pathophysiological metabolic processes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2016]
UniProt Code:O60266
NCBI GenInfo Identifier:1002341785
NCBI Gene ID:109
NCBI Accession:NP_001307542.1
UniProt Secondary Accession:O60266,Q53T54, Q9UDB1, B3KT86,
UniProt Related Accession:O60266
Molecular Weight:129 kDa
NCBI Full Name:adenylate cyclase type 3 isoform 1
NCBI Synonym Full Names:adenylate cyclase 3
NCBI Official Symbol:ADCY3  
NCBI Official Synonym Symbols:AC3; AC-III; BMIQ19  
NCBI Protein Information:adenylate cyclase type 3
UniProt Protein Name:Adenylate cyclase type 3
UniProt Synonym Protein Names:ATP pyrophosphate-lyase 3; Adenylate cyclase type III; AC-III; Adenylate cyclase, olfactive type; Adenylyl cyclase 3
Protein Family:Adenylate cyclase
UniProt Gene Name:ADCY3  
Anti-ADCY3 Antibody (CAB7870)Western blot analysis of extracts of various cell lines, using ADCY3 antibody (CAB7870) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 60s.
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