Cell Biology Antibodies 17
Anti-ADCY10 Antibody (CAB18473)
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- SKU:
- CAB18473
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADCY10 Antibody |
| Antibody SKU: | CAB18473 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant protein of human ADCY10. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant protein of human ADCY10. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 55811 |
| Uniprot: | Q96PN6 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | HCA2, HEL-S-7a, SAC, SACI, Sacy, hsAC, ADCY10 |
| Background: |
| UniProt Protein Function: | SAC: Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation. Genetic variations in ADCY10 are a cause of susceptibility to hypercalciuria absorptive type 2 (HCA2). Absorptive hypercalciuria is a common type of hypercalciuria, a condition characterized by excessive urinary calcium excretion. Absorptive hypercalciuria is due to gastrointestinal hyperabsorption of calcium and is a frequent cause of calcium oxalate nephrolithiasis. Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adenylyl cyclase; Nucleotide Metabolism - purine; Lyase; EC 4.6.1.1 Chromosomal Location of Human Ortholog: 1q24 Cellular Component: growth cone; cytoskeleton; cell soma; perinuclear region of cytoplasm; apical part of cell; axon; dendrite; cytoplasm; plasma membrane; cytosol Molecular Function:manganese ion binding; magnesium ion binding; ATPase binding; ATP binding; adenylate cyclase activity Biological Process: positive regulation of apoptosis; cAMP biosynthetic process; spermatogenesis Disease: Hypercalciuria, Absorptive, 2 |
| UniProt Code: | Q96PN6 |
| NCBI GenInfo Identifier: | 209976994 |
| NCBI Gene ID: | 55811 |
| NCBI Accession: | NP_060887 |
| Molecular Weight: | 187kDa |
| NCBI Full Name: | adenylate cyclase type 10 isoform 1 |
| UniProt Protein Name: | Adenylate cyclase type 10 |
| UniProt Synonym Protein Names: | AH-related protein; Adenylate cyclase homolog; Germ cell soluble adenylyl cyclase; hsAC; sAC; Testicular soluble adenylyl cyclase |
| Protein Family: | Sacsin |
| UniProt Gene Name: | ADCY10 |
| UniProt Entry Name: | ADCYA_HUMAN |
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