Cell Biology Antibodies 12
Anti-ADCY1 Antibody (CAB9760)
- SKU:
- CAB9760
- Product Type:
- Antibody
- Applications:
- WB
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADCY1 Antibody |
| Antibody SKU: | CAB9760 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-610 of human ADCY1 (NP_066939.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:1000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | mouse brain, mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 470-610 of human ADCY1 (NP_066939.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | NIET FFIV PSHR RKIF PGLI LSDI KPAK RMKF KTVC YLLV QLMH CRKM FKAE IPFS NVMT CEDD DKRR ALRT ASEK LRNR SSFS TNVV YTTP GTRV NRYI SRLL EARQ TELE MADL NFFT LKYK HVER EQKY HQLQ DEYF T |
| Gene ID: | 107 |
| Uniprot: | Q08828 |
| Cellular Location: | Cell membrane, Cytoplasm, Membrane, Membrane raft, Multi-pass membrane protein |
| Calculated MW: | 123kDa |
| Observed MW: | 123kDa |
| Synonyms: | ADCY1, AC1, DFNB44 |
| Background: | This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. |
| UniProt Protein Function: | ADCY1: a calmodulin-sensitive adenylyl cyclase expressed in brain. The mouse protein is involved in pattern formation of the brain. May be involved in regulatory processes in the central nervous system. It may play a role in memory acquisition and learning. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Transporter; Nucleotide Metabolism - purine; EC 4.6.1.1; Membrane protein, multi-pass; Lyase; Transporter, aquaporin family; Adenylyl cyclase Chromosomal Location of Human Ortholog: 7p12.3 Cellular Component: cytoplasm; integral to plasma membrane; lipid raft; nucleus; plasma membrane Molecular Function:adenylate cyclase activity; ATP binding; calcium- and calmodulin-responsive adenylate cyclase activity; calmodulin binding; metal ion binding Biological Process: activation of protein kinase A; axonogenesis; cAMP biosynthetic process; cAMP-mediated signaling; circadian rhythm; energy reserve metabolic process; epidermal growth factor receptor signaling pathway; fibroblast growth factor receptor signaling pathway; G-protein signaling, adenylate cyclase activating pathway; G-protein signaling, adenylate cyclase inhibiting pathway; innate immune response; long-term memory; nerve growth factor receptor signaling pathway; phospholipase C activation; regulation of circadian rhythm; renal water homeostasis; response to drug; response to lithium ion; signal transduction; synaptic transmission; transmembrane transport; water transport Disease: Deafness, Autosomal Recessive 44 |
| NCBI Summary: | This gene encodes a member of the of adenylate cyclase gene family that is primarily expressed in the brain. This protein is regulated by calcium/calmodulin concentration and may be involved in brain development. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q08828 |
| NCBI GenInfo Identifier: | 62512172 |
| NCBI Gene ID: | 107 |
| NCBI Accession: | Q08828.2 |
| UniProt Secondary Accession: | Q08828,Q75MI1, A4D2L8, |
| UniProt Related Accession: | Q08828 |
| Molecular Weight: | 123,440 Da |
| NCBI Full Name: | Adenylate cyclase type 1 |
| NCBI Synonym Full Names: | adenylate cyclase 1 (brain) |
| NCBI Official Symbol: | ADCY1 |
| NCBI Official Synonym Symbols: | AC1; DFNB44 |
| NCBI Protein Information: | adenylate cyclase type 1 |
| UniProt Protein Name: | Adenylate cyclase type 1 |
| UniProt Synonym Protein Names: | ATP pyrophosphate-lyase 1; Adenylate cyclase type I; Adenylyl cyclase 1; Ca(2+)/calmodulin-activated adenylyl cyclase |
| Protein Family: | Adenylate cyclase |
| UniProt Gene Name: | ADCY1 |
| UniProt Entry Name: | ADCY1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADCY1 antibody (CAB9760) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 90s. |
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