Signal Transduction Antibodies 2

Anti-ADCK4 Antibody (CAB14934)

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SKU:
CAB14934
Product Type:
Antibody
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ADCK4 Antibody
Antibody SKU:CAB14934
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human ADCK4 (NP_079152.3).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-90 of human ADCK4 (NP_079152.3).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MWLK VGGL LRGT GGQL GQTV GWPC GALG PGPH RWGP CGGS WAQK FYQD GPGR GLGE EDIR RARE ARPR KTPR PQLS DRSR ERKV PASR IS
Gene ID:79934
Uniprot:Q96D53
Cellular Location:Cell membrane, Cytoplasm, Mitochondrion membrane, Single-pass membrane protein, cytosol
Calculated MW:55kDa/60kDa
Observed MW:Refer to figures
Synonyms:COQ8B, ADCK4, NPHS9
Background:This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ADCK4: The function of this protein is not yet clear. It is not known if it has protein kinase activity and what type of substrate it would phosphorylate (Ser, Thr or Tyr). Belongs to the protein kinase superfamily. ADCK protein kinase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:ABC1 family; ABC1-A subfamily; ATYPICAL group; EC 2.7.-.-; EC 2.7.11.-; Kinase, protein; Membrane protein, integral; Protein kinase, Ser/Thr (non-receptor); Protein kinase, atypical

Chromosomal Location of Human Ortholog: 19q13.2

Cellular Component: cytosol; integral component of membrane; mitochondrial membrane; mitochondrion; plasma membrane

Molecular Function:ATP binding; protein kinase activity

Biological Process: cerebellar Purkinje cell layer morphogenesis; protein amino acid phosphorylation; ubiquinone biosynthetic process

Disease: Nephrotic Syndrome, Type 9

NCBI Summary:This gene encodes a protein with two copies of a domain found in protein kinases. The encoded protein has a complete protein kinase catalytic domain, and a truncated domain that contains only the active and binding sites of the protein kinase domain, however, it is not known whether the protein has any kinase activity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]
UniProt Code:Q96D53
NCBI GenInfo Identifier:217416386
NCBI Gene ID:79934
NCBI Accession:NP_001136027.1
UniProt Secondary Accession:Q96D53,Q8TAJ1, Q9HA52,
UniProt Related Accession:Q96D53
Molecular Weight:60 kDa
NCBI Full Name:atypical kinase COQ8B, mitochondrial isoform b
NCBI Synonym Full Names:coenzyme Q8B
NCBI Official Symbol:COQ8B  
NCBI Official Synonym Symbols:ADCK4; NPHS9  
NCBI Protein Information:atypical kinase COQ8B, mitochondrial
UniProt Protein Name:Atypical kinase COQ8B, mitochondrial
UniProt Synonym Protein Names:AarF domain-containing protein kinase 4
UniProt Gene Name:COQ8B  
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