Metabolism Antibodies 2

Anti-ADCK3 Antibody (CAB7378)

(No reviews yet) Write a Review
SKU:
CAB7378
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ADCK3 Antibody
Antibody SKU:CAB7378
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ADCK3 (NP_064632.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse liver, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ADCK3 (NP_064632.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAI LGDT IMVA KGLV KLTQ AAVE THLQ HLGI GGEL IMAA RALQ STAV EQIG MFLG KVQG QDKH EEYF AENF GGPE GEFH FSVP HAAG ASTD FSSA SAPD QSAP PSLG HAHS EGPA PAYV ASGP FREA GFPG QASS PLGR ANGR LFAN PRDS FSAM GFQR RFFH QDQS PVGG LTAE DIEK ARQA KARP ENKQ HKQT LSEH ARER KVPV TRIG RLAN FGGL
Gene ID:56997
Uniprot:Q8NI60
Cellular Location:Membrane, Mitochondrion, Single-pass membrane protein
Calculated MW:18kDa/42kDa/66kDa/71kDa
Observed MW:55kDa
Synonyms:COQ8A, ADCK3, ARCA2, CABC1, COQ10D4, COQ8, SCAR9
Background:This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined.
UniProt Protein Function:ADCK3: May be a chaperone-like protein essential for the proper conformation and functioning of protein complexes in the respiratory chain. Defects in ADCK3 are the cause of coenzyme Q10 deficiency, primary, type 4 (COQ10D4). An autosomal recessive disorder characterized by childhood-onset of cerebellar ataxia and exercise intolerance. Patient manifest gait ataxia and cerebellar atrophy with slow progression. Additional features include brisk tendon reflexes and Hoffmann sign, variable psychomotor retardation and variable seizures. Belongs to the protein kinase superfamily. ADCK protein kinase family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Protein kinase, atypical; EC 2.7.11.-; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); ATYPICAL group; ABC1 family; ABC1-A subfamily

Chromosomal Location of Human Ortholog: 1q42.13

Cellular Component: mitochondrion

Molecular Function:protein serine/threonine kinase activity; ATP binding

Biological Process: ubiquinone biosynthetic process; protein amino acid phosphorylation

Disease: Coenzyme Q10 Deficiency, Primary, 4

NCBI Summary:This gene encodes a mitochondrial protein similar to yeast ABC1, which functions in an electron-transferring membrane protein complex in the respiratory chain. It is not related to the family of ABC transporter proteins. Expression of this gene is induced by the tumor suppressor p53 and in response to DNA damage, and inhibiting its expression partially suppresses p53-induced apoptosis. Alternatively spliced transcript variants have been found; however, their full-length nature has not been determined. [provided by RefSeq, Jul 2008]
UniProt Code:Q8NI60
NCBI GenInfo Identifier:27923741
NCBI Gene ID:56997
NCBI Accession:Q8NI60.1
UniProt Secondary Accession:Q8NI60,Q5T7A5, Q63HK0, Q8NCJ6, Q9HBQ1, Q9NQ67,
UniProt Related Accession:Q8NI60
Molecular Weight:647
NCBI Full Name:Chaperone activity of bc1 complex-like, mitochondrial
NCBI Synonym Full Names:aarF domain containing kinase 3
NCBI Official Symbol:ADCK3  
NCBI Official Synonym Symbols:COQ8; ARCA2; CABC1; SCAR9; COQ10D4  
NCBI Protein Information:chaperone activity of bc1 complex-like, mitochondrial; coenzyme Q8 homolog; aarF domain-containing protein kinase 3; chaperone, ABC1 activity of bc1 complex homolog
UniProt Protein Name:Chaperone activity of bc1 complex-like, mitochondrial
UniProt Synonym Protein Names:aarF domain-containing protein kinase 3
UniProt Gene Name:ADCK3  
UniProt Entry Name:ADCK3_HUMAN
Anti-ADCK3 Antibody (CAB7378)Western blot analysis of extracts of various cell lines, using ADCK3 antibody (CAB7378) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
Anti-ADCK3 Antibody (CAB7378)Immunohistochemistry of paraffin-embedded rat liver using ADCK3 antibody (CAB7378) at dilution of 1:100 (40x lens).
Anti-ADCK3 Antibody (CAB7378)Immunohistochemistry of paraffin-embedded human kidney using ADCK3 antibody (CAB7378) at dilution of 1:100 (40x lens).
Anti-ADCK3 Antibody (CAB7378)Immunohistochemistry of paraffin-embedded mouse kidney using ADCK3 antibody (CAB7378) at dilution of 1:100 (40x lens).
View AllClose

0 Reviews

View AllClose

Related Products