Immunology Antibodies 2
Anti-ADARB1 Antibody (CAB16748)
- SKU:
- CAB16748
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
Antibody Name: | Anti-ADARB1 Antibody |
Antibody SKU: | CAB16748 |
Antibody Size: | 20uL, 50uL, 100uL |
Application: | WB |
Reactivity: | Human, Mouse, Rat |
Host Species: | Rabbit |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human ADARB1 (NP_001103.1). |
Application: | WB |
Recommended Dilution: | WB 1:500 - 1:2000 |
Reactivity: | Human, Mouse, Rat |
Positive Samples: | U-251MG, HeLa, Jurkat, HepG2, mouse brain, mouse lung, mouse testis, rat brain |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human ADARB1 (NP_001103.1). |
Purification Method: | Affinity purification |
Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | FETP DKAE PPFY VGSN GDDS FSSS GDLS LSAS PVPA SLAQ PPLP VLPP FPPP SGKN PVMI LNEL RPGL KYDF LSES GESH AKSF VMSV VVDG QFFE GSGR NKKL AKAR AAQS ALAA IFNL HLDQ TPSR QPIP SEGL QLHL PQVL ADAV SRLV LGKF GDLT DNFS SPHA RRKV LAGV VMTT GTDV KDAK VISV STGT KCIN G |
Gene ID: | 104 |
Uniprot: | P78563 |
Cellular Location: | |
Calculated MW: | 80kDa |
Observed MW: | 81kDa |
Synonyms: | ADARB1, ADAR2, DRABA2, DRADA2, RED1 |
Background: | This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. |
UniProt Protein Function: | Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins; pre-mRNA splicing by altering splice site recognition sequences; RNA stability by changing sequences involved in nuclease recognition; genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication; and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. |
NCBI Summary: | This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. [provided by RefSeq, Jul 2008] |
UniProt Code: | P78563 |
NCBI GenInfo Identifier: | 4501919 |
NCBI Gene ID: | 104 |
NCBI Accession: | NP_001103.1 |
UniProt Secondary Accession: | P78563,O00395, O00465, O00691, O00692, P78555, A6NFK8 A6NJ84, C3TTQ1, C3TTQ2, C9JUP4, G5E9B4, |
UniProt Related Accession: | P78563 |
Molecular Weight: | 73,665 Da |
NCBI Full Name: | double-stranded RNA-specific editase 1 isoform 1 |
NCBI Synonym Full Names: | adenosine deaminase, RNA specific B1 |
NCBI Official Symbol: | ADARB1 |
NCBI Official Synonym Symbols: | RED1; ADAR2; DRABA2; DRADA2 |
NCBI Protein Information: | double-stranded RNA-specific editase 1 |
UniProt Protein Name: | Double-stranded RNA-specific editase 1 |
UniProt Synonym Protein Names: | RNA-editing deaminase 1; RNA-editing enzyme 1; dsRNA adenosine deaminase |
UniProt Gene Name: | ADARB1 |
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