Cell Death Antibodies 2

Anti-ADAMTSL4 Antibody (CAB4785)

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SKU:
CAB4785
Product Type:
Antibody
Antibody Type:
Polyclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
ADAMTSL4
Synonyms:
ADAMTSL-4
Synonyms:
ECTOL2
Synonyms:
TSRC1
Research Area:
Cell Death

Description

Product Name:ADAMTSL4 Rabbit pAb
Product Code:CAB4785
Size:20uL, 50uL, 100uL
Synonyms:ADAMTSL4, ADAMTSL-4, ECTOL2, TSRC1
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 795-1074 of human ADAMTSL4 (NP_061905.2).
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:100
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse brain, Mouse lung, Rat lung
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 795-1074 of human ADAMTSL4 (NP_061905.2).
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:CSVR CGRG QRSR QVRC VGNN GDEV SEQE CASG PPQP PSRE ACDM GPCT TAWF HSDW SSKC SAEC GTGI QRRS VVCL GSGA ALGP GQGE AGAG TGQS CPTG SRPP DMRA CSLG PCER TWRW YTGP WGEC SSEC GSGT QRRD IICV SKLG TEFN VTSP SNCS HLPR PPAL QPCQ GQAC QDRW FSTP WSPC SRSC QGGT QTRE VQCL STNQ TLST RCPP QLRP SRKR PCNS QPCS QRPD DQCK DSSP HCPL VVQA RLCV YPYY TATC CRSC AHVL ERSP QDPS
Gene ID:54507
Uniprot:Q6UY14
Cellular Location:Secreted, extracellular matrix, extracellular space
Calculated MW:95kDa/116kDa/118kDa
Observed MW:116kDa
UniProt Protein Function:TSRC1: Positive regulation of apoptosis. May facilitate FBN1 microfibril biogenesis. Defects in ADAMTSL4 are a cause of autosomal recessive isolated ectopia lentis (ARI-EL). ARI-EL is a rare condition characterized by partial or complete displacement of the lens from its space resulting from defective zonule formation. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Secreted, signal peptide; Secreted

Chromosomal Location of Human Ortholog: 1q21.3

Cellular Component: endoplasmic reticulum lumen

Molecular Function:protein binding; protease binding; metalloendopeptidase activity

Biological Process: protein amino acid O-linked glycosylation; extracellular matrix organization and biogenesis; cellular protein metabolic process; apoptosis; positive regulation of apoptosis; proteolysis; post-translational protein modification

Disease: Ectopia Lentis 2, Isolated, Autosomal Recessive; Ectopia Lentis Et Pupillae

NCBI Summary:This gene is a member of ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs)-like gene family and encodes a protein with seven thrombospondin type 1 repeats. The thrombospondin type 1 repeat domain is found in many proteins with diverse biological functions including cellular adhesion, angiogenesis, and patterning of the developing nervous system. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Sep 2014]
UniProt Code:Q6UY14
NCBI GenInfo Identifier:118573317
NCBI Gene ID:54507
NCBI Accession:Q6UY14.2
UniProt Secondary Accession:Q6UY14,Q5T5F7, Q6IPM6, Q8N643, Q9HBS6, B2RTT0, F8WAD0
UniProt Related Accession:Q6UY14
Molecular Weight:1074
NCBI Full Name:ADAMTS-like protein 4
NCBI Synonym Full Names:ADAMTS-like 4
NCBI Official Symbol:ADAMTSL4  
NCBI Official Synonym Symbols:TSRC1; ECTOL2; ADAMTSL-4  
NCBI Protein Information:ADAMTS-like protein 4; thrombospondin repeat-containing protein 1
UniProt Protein Name:ADAMTS-like protein 4
UniProt Synonym Protein Names:Thrombospondin repeat-containing protein 1
Protein Family:ADAMTS-like protein
UniProt Gene Name:ADAMTSL4  
UniProt Entry Name:ATL4_HUMAN
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