Cell Biology Antibodies 14
Anti-ADAMTS7 Antibody (CAB17093)
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- SKU:
- CAB17093
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADAMTS7 Antibody |
| Antibody SKU: | CAB17093 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | SH-SY5Y |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11173 |
| Uniprot: | Q9UKP4 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 200kDa |
 | Western blot - ADAMTS7 Polyclonal Antibody (CAB17093) |
| Synonyms: | ADAMTS7, ADAM-TS 7, ADAM-TS7, ADAMTS-7 |
| Background: | The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. |
| UniProt Protein Function: | ADAMTS7: Metalloprotease that may play a role in the degradation of COMP. |
| UniProt Protein Details: | Protein type:Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide Chromosomal Location of Human Ortholog: 15q25.1 Cellular Component: endoplasmic reticulum lumen Molecular Function:metalloendopeptidase activity; metallopeptidase activity; protein binding Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process |
| NCBI Summary: | The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9UKP4 |
| NCBI GenInfo Identifier: | 38683827 |
| NCBI Gene ID: | 11173 |
| NCBI Accession: | NP_055087.2 |
| UniProt Secondary Accession: | Q9UKP4,Q14F51, Q6P7J9, |
| UniProt Related Accession: | Q9UKP4 |
| Molecular Weight: | 55.12kD |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 7 |
| NCBI Official Symbol: | ADAMTS7 |
| NCBI Official Synonym Symbols: | ADAM-TS7; ADAMTS-7; ADAM-TS 7 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 7 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 7 |
| UniProt Synonym Protein Names: | COMPase |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS7 |
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