Name: Anti-ADAMTS5 Antibody (CAB2836)
Brand: Cell Biology Antibodies 8
SKU: CAB2836
Availability: OutOfStock

Antibody Name:	Anti-ADAMTS5 Antibody
Antibody SKU:	CAB2836
Antibody Size:	20uL, 50uL, 100uL
Application:	WB
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2).

Application:	WB
Recommended Dilution:	WB 1:500 - 1:2000
Reactivity:	Human, Mouse, Rat
Positive Samples:	Rat liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	Email for sequence
Gene ID:	11096
Uniprot:	Q9UNA0
Cellular Location:	Secreted, extracellular matrix, extracellular space
Calculated MW:	101kDa
Observed MW:	73KDa

Synonyms:

ADAMTS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, ADAM-TS11

Background:

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis.

UniProt Protein Function:	ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period.
UniProt Protein Details:	Protein type:Extracellular matrix; Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region Molecular Function:integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification
NCBI Summary:	This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016]
UniProt Code:	Q9UNA0
NCBI GenInfo Identifier:	317373326
NCBI Gene ID:	11096
NCBI Accession:	Q9UNA0.2
UniProt Related Accession:	Q9UNA0
Molecular Weight:
NCBI Full Name:	A disintegrin and metalloproteinase with thrombospondin motifs 5
NCBI Synonym Full Names:	ADAM metallopeptidase with thrombospondin type 1 motif 5
NCBI Official Symbol:	ADAMTS5
NCBI Official Synonym Symbols:	ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11
NCBI Protein Information:	A disintegrin and metalloproteinase with thrombospondin motifs 5
UniProt Protein Name:	A disintegrin and metalloproteinase with thrombospondin motifs 5
UniProt Synonym Protein Names:	A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2
UniProt Gene Name:	ADAMTS5
UniProt Entry Name:	ATS5_HUMAN

Western blot analysis of extracts of Rat liver, using ADAMTS5 Rabbit pAb (CAB2836) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.

ELISA Kits

Human ADAMTS5 ELISA Kit

Human A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) ELISA Kit

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)