Cell Biology Antibodies 8
Anti-ADAMTS5 Antibody (CAB2836)
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- SKU:
- CAB2836
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADAMTS5 Antibody |
| Antibody SKU: | CAB2836 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 731-930 of human ADAMTS5 (NP_008969.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11096 |
| Uniprot: | Q9UNA0 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 101kDa |
| Observed MW: | 73KDa |
| Synonyms: | ADAMTS5, ADAM-TS 11, ADAM-TS 5, ADAM-TS5, ADAMTS-11, ADAMTS-5, ADAMTS11, ADMP-2, ADAM-TS11 |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. |
| UniProt Protein Function: | ADAMTS5: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. May play a role in proteolytic processing mostly during the peri-implantation period. |
| UniProt Protein Details: | Protein type:Extracellular matrix; Secreted; EC 3.4.24.-; Protease; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 21q21.3 Cellular Component: proteinaceous extracellular matrix; endoplasmic reticulum lumen; extracellular region Molecular Function:integrin binding; protein binding; metallopeptidase activity; zinc ion binding; metalloendopeptidase activity Biological Process: protein amino acid O-linked glycosylation; extracellular matrix disassembly; extracellular matrix organization and biogenesis; cellular protein metabolic process; defense response to bacterium; proteolysis; post-translational protein modification |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and functions as an aggrecanase that cleaves aggrecan, a major proteoglycan of cartilage, and may mediate cartilage destruction in osteoarthritis. [provided by RefSeq, Feb 2016] |
| UniProt Code: | Q9UNA0 |
| NCBI GenInfo Identifier: | 317373326 |
| NCBI Gene ID: | 11096 |
| NCBI Accession: | Q9UNA0.2 |
| UniProt Related Accession: | Q9UNA0 |
| Molecular Weight: | |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 5 |
| NCBI Official Symbol: | ADAMTS5 |
| NCBI Official Synonym Symbols: | ADMP-2; ADAM-TS5; ADAMTS-5; ADAMTS11; ADAM-TS 5; ADAMTS-11; ADAM-TS 11 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 5 |
| UniProt Synonym Protein Names: | A disintegrin and metalloproteinase with thrombospondin motifs 11; ADAM-TS 11; ADAMTS-11; ADMP-2; Aggrecanase-2 |
| UniProt Gene Name: | ADAMTS5 |
| UniProt Entry Name: | ATS5_HUMAN |
 | Western blot analysis of extracts of Rat liver, using ADAMTS5 Rabbit pAb (CAB2836) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
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