Anti-ADAMTS13 Antibody (CAB3370)
- SKU:
- CAB3370
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ADAM-TS13
- Synonyms:
- ADAMTS-13
- Synonyms:
- C9orf8
- Synonyms:
- VWFCP
- Synonyms:
- vWF-CP
- Research Area:
- Cardiovascular
Description
| Product Name: | ADAMTS13 Rabbit mAb |
| Product Code: | CAB3370 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ADAM-TS13, ADAMTS-13, C9orf8, VWFCP, vWF-CP |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ADAMTS13 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse liver, Mouse spleen, Mouse plasma, Rat plasma |
| Immunogen: | A synthesized peptide derived from human ADAMTS13 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 11093 |
| Uniprot: | Q76LX8 |
| Calculated MW: | 154kDa |
| Observed MW: | 190KDa |
| UniProt Protein Function: | ADAMTS13: Cleaves the vWF multimers in plasma into smaller forms. Defects in ADAMTS13 are the cause of thrombotic thrombocytopenic purpura congenital (TTP); also known as Upshaw-Schulman syndrome (USS). A hematologic disease characterized by hemolytic anemia with fragmentation of erythrocytes, thrombocytopenia, diffuse and non-focal neurologic findings, decreased renal function and fever. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Calcium-binding; Secreted, signal peptide; Secreted; Protease; EC 3.4.24.87; Extracellular matrix Chromosomal Location of Human Ortholog: 9q34 Cellular Component: endoplasmic reticulum lumen; proteinaceous extracellular matrix Molecular Function:calcium ion binding; integrin binding; metallopeptidase activity; protein binding; zinc ion binding Biological Process: peptide catabolic process; protein processing; proteolysis Disease: Thrombotic Thrombocytopenic Purpura, Congenital |
| NCBI Summary: | This gene encodes a member of a family of proteins containing several distinct regions, including a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. The enzyme encoded by this gene specifically cleaves von Willebrand Factor (vWF). Defects in this gene are associated with thrombotic thrombocytopenic purpura. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013] |
| UniProt Code: | Q76LX8 |
| NCBI GenInfo Identifier: | 74749836 |
| NCBI Gene ID: | 11093 |
| NCBI Accession: | Q76LX8.1 |
| UniProt Secondary Accession: | Q76LX8,Q6UY16, Q710F6, Q711T8, Q96L37, Q9H0G3, Q9UGQ1 |
| UniProt Related Accession: | Q76LX8 |
| Molecular Weight: | 39,864 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 13 |
| NCBI Official Symbol: | ADAMTS13 |
| NCBI Official Synonym Symbols: | VWFCP; C9orf8; vWF-CP; ADAM-TS13; ADAMTS-13 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 13 |
| UniProt Synonym Protein Names: | von Willebrand factor-cleaving protease; vWF-CP; vWF-cleaving protease |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS13 |
| UniProt Entry Name: | ATS13_HUMAN |
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