Cell Biology Antibodies 6
Anti-ADAMTS1 Antibody (CAB15356)
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- SKU:
- CAB15356
- Product Type:
- Antibody
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ADAMTS1 Antibody |
| Antibody SKU: | CAB15356 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 718-967 of human ADAMTS1 (NP_008919.3). |
| Application: | WB |
| Recommended Dilution: | WB 1:200 - 1:2000 |
| Reactivity: | Mouse, Rat |
| Positive Samples: | Mouse kidney, Mouse brain, Mouse liver, Rat brain, Rat liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 718-967 of human ADAMTS1 (NP_008919.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | GGNG STCK KISG SVTS AKPG YHDI ITIP TGAT NIEV KQRN QRGS RNNG SFLA IKAA DGTY ILNG DYTL STLE QDIM YKGV VLRY SGSS AALE RIRS FSPL KEPL TIQV LTVG NALR PKIK YTYF VKKK KESF NAIP TFSA WVIE EWGE CSKS CELG WQRR LVEC RDIN GQPA SECA KEVK PAST RPCA DHPC PQWQ LGEW SSCS KTCG KGYK KRSL KCLS HDGG VLSH ESCD PLKK PKHF IDFC TMAE CS |
| Gene ID: | 9510 |
| Uniprot: | Q9UHI8 |
| Cellular Location: | Secreted, extracellular matrix, extracellular space |
| Calculated MW: | 105kDa |
| Observed MW: | 105kDa |
| Synonyms: | ADAMTS1, C3-C5, METH1 |
| Background: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. |
| UniProt Protein Function: | ADAMTS1: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. |
| UniProt Protein Details: | Protein type:Protease; Secreted, signal peptide; Motility/polarity/chemotaxis; EC 3.4.24.-; Secreted Chromosomal Location of Human Ortholog: 21q21.2 Cellular Component: basement membrane; cytoplasm; cytoplasmic vesicle Molecular Function:heparin binding; metalloendopeptidase activity; metallopeptidase activity; zinc ion binding Biological Process: integrin-mediated signaling pathway; kidney development; negative regulation of cell proliferation; ovulation from ovarian follicle; proteolysis |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The protein encoded by this gene contains two disintegrin loops and three C-terminal TS motifs and has anti-angiogenic activity. The expression of this gene may be associated with various inflammatory processes as well as development of cancer cachexia. This gene is likely to be necessary for normal growth, fertility, and organ morphology and function. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9UHI8 |
| NCBI GenInfo Identifier: | 124053460 |
| NCBI Gene ID: | 9510 |
| NCBI Accession: | Q9UHI8.4 |
| UniProt Secondary Accession: | Q9UHI8,Q9NSJ8, Q9P2K0, Q9UH83, Q9UP80, D3DSD5, |
| UniProt Related Accession: | Q9UHI8 |
| Molecular Weight: | 105,358 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif 1 |
| NCBI Official Symbol: | ADAMTS1 |
| NCBI Official Synonym Symbols: | C3-C5; METH1 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 1 |
| UniProt Synonym Protein Names: | METH-1 |
| Protein Family: | A disintegrin and metalloproteinase with thrombospondin motifs |
| UniProt Gene Name: | ADAMTS1 |
| UniProt Entry Name: | ATS1_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADAMTS1 antibody (CAB15356) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s. |
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