Cell Biology Antibodies 4

Anti-ADAM23 Antibody (CAB14263)

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SKU:
CAB14263
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ADAM23 Antibody
Antibody SKU:CAB14263
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-500 of human ADAM23 (NP_003803.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:293T, Raji, Mouse heart
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 350-500 of human ADAM23 (NP_003803.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:VETW TEKD QIDI TTNP VQML HEFS KYRQ RIKQ HADA VHLI SRVT FHYK RSSL SYFG GVCS RTRG VGVN EYGL PMAV AQVL SQSL AQNL GIQW EPSS RKPK CDCT ESWG GCIM EETG VSHS RKFS KCSI LEYR DFLQ RGGG ACLF NRPT KLF
Gene ID:8745
Uniprot:O75077
Cellular Location:Cell membrane, Secreted, Single-pass type I membrane protein
Calculated MW:91kDa/92kDa
Observed MW:92kDa
Synonyms:ADAM23, MDC-3, MDC3
Background:This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers.
UniProt Protein Function:ADAM23: May play a role in cell-cell and cell-matrix interactions. This is a non-catalytic metalloprotease-like protein. 3 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Motility/polarity/chemotaxis; Cell adhesion

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:integrin binding; metallopeptidase activity; protein binding

Biological Process: central nervous system development

NCBI Summary:This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. It is reported that inactivation of this gene is associated with tumorigenesis in human cancers. [provided by RefSeq, May 2013]
UniProt Code:O75077
NCBI GenInfo Identifier:56404446
NCBI Gene ID:8745
NCBI Accession:O75077.1
UniProt Secondary Accession:O75077,A2RU59,
UniProt Related Accession:O75077
Molecular Weight:92,130 Da
NCBI Full Name:Disintegrin and metalloproteinase domain-containing protein 23
NCBI Synonym Full Names:ADAM metallopeptidase domain 23
NCBI Official Symbol:ADAM23  
NCBI Official Synonym Symbols:MDC3; MDC-3  
NCBI Protein Information:disintegrin and metalloproteinase domain-containing protein 23
UniProt Protein Name:Disintegrin and metalloproteinase domain-containing protein 23
UniProt Synonym Protein Names:Metalloproteinase-like, disintegrin-like, and cysteine-rich protein 3; MDC-3
Protein Family:Disintegrin and metalloproteinase domain-containing protein
UniProt Gene Name:ADAM23  
UniProt Entry Name:ADA23_HUMAN
Anti-ADAM23 Antibody (CAB14263)Western blot analysis of extracts of various cell lines, using ADAM23 antibody (CAB14263) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
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