Cell Biology Antibodies 11
Anti-ACVR2B Antibody (CAB7868)
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- SKU:
- CAB7868
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ACVR2B Antibody |
| Antibody SKU: | CAB7868 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACVR2B (NP_001097.2). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | U-87MG, K-562 |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACVR2B (NP_001097.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | EGEQ DKRL HCYA SWRN SSGT IELV KKGC WLDD FNCY DRQE CVAT EENP QVYF CCCE GNFC NERF THLP EAGG PEVT YEPP PTAP TLLT VLAY SLLP IGGL S |
| Gene ID: | 93 |
| Uniprot: | Q13705 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 57kDa |
| Observed MW: | 58kDa |
| Synonyms: | ACVR2B, ACTRIIB, ActR-IIB, HTX4 |
| Background: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. |
| UniProt Protein Function: | ACVR2B: a tyrosine-kinase like receptor kinase of the STKR family. The holoreceptor receptor is a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. Each is composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic kinase domain. Type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptor kinases are apparently constitutively active. The IIB receptor displays a 3- to 4-fold higher affinity for activin A than the II receptor. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Protein kinase, TKL; Kinase, protein; TKL group; STKR family; Type2 subfamily Chromosomal Location of Human Ortholog: 3p22 Cellular Component: integral to plasma membrane; cytoplasm; plasma membrane; receptor complex Molecular Function:transforming growth factor beta receptor activity; protein serine/threonine kinase activity; protein binding; growth factor binding; metal ion binding; protein serine/threonine/tyrosine kinase activity; activin binding; activin receptor activity, type II; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: heart development; activin receptor signaling pathway; palate development; signal transduction; protein amino acid phosphorylation; post-embryonic development; BMP signaling pathway; anterior/posterior pattern formation; positive regulation of activin receptor signaling pathway; regulation of transcription, DNA-dependent; embryonic foregut morphogenesis; pancreas development; transmembrane receptor protein serine/threonine kinase signaling pathway; lymphangiogenesis; response to glucose stimulus; mesoderm development; kidney development; gastrulation with mouth forming second; positive regulation of bone mineralization; odontogenesis of dentine-containing teeth; organ growth; positive regulation of osteoblast differentiation; insulin secretion; skeletal morphogenesis; activation of protein kinase activity; blood vessel remodeling; determination of left/right symmetry; lung development Disease: Heterotaxy, Visceral, 4, Autosomal |
| NCBI Summary: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q13705 |
| NCBI GenInfo Identifier: | 97535735 |
| NCBI Gene ID: | 93 |
| NCBI Accession: | Q13705.3 |
| UniProt Secondary Accession: | Q13705,Q4VAV0, |
| UniProt Related Accession: | Q13705 |
| Molecular Weight: | Da |
| NCBI Full Name: | Activin receptor type-2B |
| NCBI Synonym Full Names: | activin A receptor, type IIB |
| NCBI Official Symbol: | ACVR2B |
| NCBI Official Synonym Symbols: | HTX4; ACTRIIB; ActR-IIB |
| NCBI Protein Information: | activin receptor type-2B |
| UniProt Protein Name: | Activin receptor type-2B |
| UniProt Synonym Protein Names: | Activin receptor type IIB; ACTR-IIB |
| Protein Family: | Activin receptor |
| UniProt Gene Name: | ACVR2B |
| UniProt Entry Name: | AVR2B_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACVR2B antibody (CAB7868) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
 | Immunofluorescence analysis of HeLa cells using ACVR2B antibody (CAB7868) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining. |
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