Name: Anti-ACVR1C Antibody (CAB0678)
Brand: Cell Death Antibodies 1
SKU: CAB0678
Availability: OutOfStock

Antibody Name:	Anti-ACVR1C Antibody
Antibody SKU:	CAB0678
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_660302.2).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:100 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:	SH-SY5Y

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_660302.2).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	LSPG LKCV CLLC DSSN FTCQ TEGA CWAS VMLT NGKE QVIK SCVS LPEL NAQV FCHS SNNV TKTE CCFT DFCN NITL HLPT ASPN APKL GPME
Gene ID:	130399
Uniprot:	Q8NER5
Cellular Location:	Membrane, Single-pass type I membrane protein
Calculated MW:	37kDa/46kDa/49kDa/54kDa
Observed MW:	60kDa

Synonyms:	ACVR1C, ACVRLK7, ALK7
Background:

UniProt Protein Function:	ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 2q24.1 Cellular Component: plasma membrane; activin receptor complex Molecular Function:transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus
NCBI Summary:	ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008]
UniProt Code:	Q8NER5
NCBI GenInfo Identifier:	74762565
NCBI Gene ID:	130399
NCBI Accession:	Q8NER5.1
UniProt Secondary Accession:	Q8NER5,Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2,
UniProt Related Accession:	Q8NER5
Molecular Weight:	Calculated MW: 37kDa/46kDa/49kDa/54kDaObserved MW: 60kDa
NCBI Full Name:	Activin receptor type-1C
NCBI Synonym Full Names:	activin A receptor, type IC
NCBI Official Symbol:	ACVR1C
NCBI Official Synonym Symbols:	ALK7; ACVRLK7
NCBI Protein Information:	activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7
UniProt Protein Name:	Activin receptor type-1C
UniProt Synonym Protein Names:	Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
Protein Family:	Activin receptor
UniProt Gene Name:	ACVR1C
UniProt Entry Name:	ACV1C_HUMAN

	Western blot analysis of extracts of SH-SY5Y cells, using ACVR1C antibody (CAB0678) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
	Immunohistochemistry of paraffin-embedded rat brain using ACVR1C antibody (CAB0678) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded human stomach using ACVR1C antibody (CAB0678) at dilution of 1:100 (40x lens).
	Immunohistochemistry of paraffin-embedded mouse stomach using ACVR1C antibody (CAB0678) at dilution of 1:100 (40x lens).