Description
| Product Name: | ACTN3 Rabbit mAb |
| Product Code: | CAB19631 |
| Size: | 20uL, 50uL, 100uL |
| Applications: | WB, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ACTN3 |
| Applications: | WB, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | Mouse skeletal muscle, Rat skeletal muscle |
| Immunogen: | A synthesized peptide derived from human ACTN3 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 89 |
| Uniprot: | Q08043 |
| Calculated MW: | 103kDa |
| Observed MW: | 103KDa |
| UniProt Protein Function: | ACTN3: F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Belongs to the alpha-actinin family. |
| UniProt Protein Details: | Protein type:Cytoskeletal; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13.2 Cellular Component: actin filament; cytosol; focal adhesion; intracellular; pseudopodium Molecular Function:integrin binding; protein binding; protein homodimerization activity; structural constituent of muscle Biological Process: focal adhesion formation; muscle filament sliding; negative regulation of glycolysis; positive regulation of skeletal muscle growth; regulation of the force of skeletal muscle contraction; response to denervation involved in regulation of muscle adaptation; skeletal muscle atrophy; transition between fast and slow fiber |
| NCBI Summary: | This gene encodes a member of the alpha-actin binding protein gene family. The encoded protein is primarily expressed in skeletal muscle and functions as a structural component of sarcomeric Z line. This protein is involved in crosslinking actin containing thin filaments. An allelic polymorphism in this gene results in both coding and non-coding variants; the reference genome represents the coding allele. The non-functional allele of this gene is associated with elite athlete status. [provided by RefSeq, Feb 2014] |
| UniProt Code: | Q08043 |
| NCBI GenInfo Identifier: | 215273967 |
| NCBI Gene ID: | 89 |
| NCBI Accession: | Q08043.2 |
| UniProt Secondary Accession: | Q08043,Q4KKV2, A6NP77, |
| UniProt Related Accession: | Q08043 |
| Molecular Weight: | 103kDa |
| NCBI Full Name: | Alpha-actinin-3 |
| NCBI Synonym Full Names: | actinin alpha 3 (gene/pseudogene) |
| NCBI Official Symbol: | ACTN3Â Â |
| NCBI Protein Information: | alpha-actinin-3 |
| UniProt Protein Name: | Alpha-actinin-3 |
| UniProt Synonym Protein Names: | Alpha-actinin skeletal muscle isoform 3; F-actin cross-linking protein |
| Protein Family: | Alpha-actinin |
| UniProt Gene Name: | ACTN3Â Â |
