Epigenetics & Nuclear Signaling Antibodies 5
Anti-ACTL6A Antibody (CAB7709)
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- SKU:
- CAB7709
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Epigenetics and Nuclear Signaling
Description
| Antibody Name: | Anti-ACTL6A Antibody |
| Antibody SKU: | CAB7709 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ACTL6A |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | MCF7, NIH/3T3, C6 |
| Immunogen: | A synthesized peptide derived from human ACTL6A |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 86 |
| Uniprot: | O96019 |
| Cellular Location: | |
| Calculated MW: | 47kDa |
| Observed MW: | 47KDa |
| Synonyms: | ACTL6, ARPN-BETA, Arp4, BAF53A, INO80K |
| Background: | This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | BAF53A: an actin-related protein involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for maximal ATPase activity of the helicase SMARCA4 and for association of the SMARCA4 containing remodelling complex BAF with chromatin/nuclear matrix. A component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of specific genes. Two alternatively spliced human isoforms have been described. |
| UniProt Protein Details: | Chromosomal Location of Human Ortholog: 3q26.33 Cellular Component: NuA4 histone acetyltransferase complex; nuclear chromatin; nucleoplasm; nucleus; plasma membrane; protein complex; SWI/SNF complex Molecular Function:chromatin binding; nucleosomal DNA binding; protein binding Biological Process: ATP-dependent chromatin remodeling; chromatin remodeling; signal transduction |
| NCBI Summary: | This gene encodes a family member of actin-related proteins (ARPs), which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a 53 kDa subunit protein of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. Together with beta-actin, it is required for maximal ATPase activity of BRG1, and for the association of the BAF complex with chromatin/matrix. Three transcript variants that encode two different protein isoforms have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O96019 |
| NCBI GenInfo Identifier: | 23396463 |
| NCBI Gene ID: | 86 |
| NCBI Accession: | O96019.1 |
| UniProt Secondary Accession: | O96019,Q8TAE5, Q9BVS8, Q9H0W6, B3KMN1, D3DNR9, |
| UniProt Related Accession: | O96019 |
| Molecular Weight: | 43,236 Da |
| NCBI Full Name: | Actin-like protein 6A |
| NCBI Synonym Full Names: | actin like 6A |
| NCBI Official Symbol: | ACTL6A |
| NCBI Official Synonym Symbols: | Arp4; ACTL6; BAF53A; INO80K; ARPN-BETA |
| NCBI Protein Information: | actin-like protein 6A |
| UniProt Protein Name: | Actin-like protein 6A |
| UniProt Synonym Protein Names: | 53 kDa BRG1-associated factor A; Actin-related protein Baf53a; ArpNbeta; BRG1-associated factor 53A; BAF53A; INO80 complex subunit K |
| Protein Family: | Actin-like protein |
| UniProt Gene Name: | ACTL6A |
| UniProt Entry Name: | ACL6A_HUMAN |
 | Western blot - ACTL6A Rabbit mAb (CAB7709) |
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