Description
| Antibody Name: | ACSL6 Rabbit Polyclonal Antibody |
| Antibody SKU: | CAB7965 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-622 of human ACSL6 (NP_001192180.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 22Rv1, Jurkat, Raji, THP-1, Mouse brain, Mouse testis, Mouse heart, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 383-622 of human ACSL6 (NP_001192180.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | YGQT ECTA GCTF TTPG DWTS GHVG APLP CNHI KLVD VEEL NYWA CKGE GEIC VRGP NVFK GYLK DPDR TKEA LDSD GWLH TGDI GKWL PAGT LKII DRKK HIFK LAQG EYVA PEKI ENIY IRSQ PVAQ IYVH GDSL KAFL VGIV VPDP EVMP SWAQ KRGI EGTY ADLC TNKD LKKA ILED MVRL GKES GLHS FEQV KAIH IHSD MFSV QNGL LTPT LKAK RPEL REYF KKQI EELY SISM |
| Gene ID: | 23305 |
| Uniprot: | Q9UKU0 |
| Cellular Location: | Endoplasmic reticulum membrane, Microsome membrane, Mitochondrion outer membrane, Peroxisome membrane, Single-pass type III membrane protein |
| Calculated MW: | 69kDa/74kDa/76kDa/77kDa/79kDa/80kDa |
| Observed MW: | 77kDa |
| Synonyms: | ACSL6, ACS2, FACL6, LACS 6, LACS2, LACS5, LACS6 |
| Background: | The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ACSL6: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6. A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6. Belongs to the ATP-dependent AMP-binding enzyme family. 8 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Lipid Metabolism - fatty acid; EC 6.2.1.3; Membrane protein, integral; Ligase Chromosomal Location of Human Ortholog: 5q31.1 Cellular Component: endoplasmic reticulum membrane Molecular Function:long-chain-fatty-acid-CoA ligase activity; protein homodimerization activity |
| NCBI Summary: | The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011] |
| UniProt Code: | Q9UKU0 |
| NCBI GenInfo Identifier: | 146322303 |
| NCBI Gene ID: | 23305 |
| NCBI Accession: | Q9UKU0.4 |
| UniProt Secondary Accession: | Q9UKU0,O94924, O95829, Q108M9, Q108N0, Q4G191, Q86TN7 J3KPG3, |
| UniProt Related Accession: | Q9UKU0 |
| Molecular Weight: | 79,040 Da |
| NCBI Full Name: | Long-chain-fatty-acid--CoA ligase 6 |
| NCBI Synonym Full Names: | acyl-CoA synthetase long-chain family member 6 |
| NCBI Official Symbol: | ACSL6 |
| NCBI Official Synonym Symbols: | ACS2; FACL6; LACS2; LACS5; LACS 6 |
| NCBI Protein Information: | long-chain-fatty-acid--CoA ligase 6 |
| UniProt Protein Name: | Long-chain-fatty-acid--CoA ligase 6 |
| UniProt Synonym Protein Names: | Long-chain acyl-CoA synthetase 6; LACS 6 |
| Protein Family: | Long-chain-fatty-acid--CoA ligase |
| UniProt Gene Name: | ACSL6 |
| UniProt Entry Name: | ACSL6_HUMAN |
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