Antibody Name:	Anti-ACSL1 Antibody
Antibody SKU:	CAB17482
Antibody Size:	20uL, 50 uL
Application:	WB IF
Reactivity:	Human, Mouse, Rat
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 46-275 of human ACSL1 (NP_001273637.1).

Application:	WB IF
Recommended Dilution:	WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:	Human, Mouse, Rat
Positive Samples:

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 46-275 of human ACSL1 (NP_001273637.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	TRPK PLKP PCDL SMQS VEVA GSGG ARRS ALLD SDEP LVYF YDDV TTLY EGFQ RGIQ VSNN GPCL GSRK PDQP YEWL SYKQ VAEL SECI GSAL IQKG FKTA PDQF IGIF AQNR PEWV IIEQ GCFA YSMV IVPL YDTL GNEA ITYI VNKA ELSL VFVD KPEK AKLL LEGV ENKL IPGL KIIV VMDA YGSE LVER GQRC GVEV TSMK AMED LGRA NRRK PKPP APED LAVI CF
Gene ID:	2180
Uniprot:	P33121
Cellular Location:
Calculated MW:	76kDa/77kDa
Observed MW:	Refer to figures

Synonyms:

ACS1, FACL1, FACL2, LACS, LACS1, LACS2, ACSL1

Background:

The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

UniProt Protein Function:	ACSL1: Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses palmitoleate, oleate and linoleate. Highly expressed in liver, heart, skeletal muscle, kidney and erythroid cells, and to a lesser extent in brain, lung, placenta and pancreas. Belongs to the ATP-dependent AMP-binding enzyme family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:	Protein type:Lipid Metabolism - fatty acid; Ligase; Membrane protein, integral; EC 6.2.1.3 Chromosomal Location of Human Ortholog: 4q35.1 Cellular Component: peroxisomal membrane; mitochondrial outer membrane; endoplasmic reticulum membrane; mitochondrion; membrane; plasma membrane; integral to membrane Molecular Function:ATP binding; long-chain-fatty-acid-CoA ligase activity Biological Process: response to drug; response to oleate; unsaturated fatty acid metabolic process; lipid biosynthetic process; linoleic acid metabolic process; adiponectin-mediated signaling pathway; triacylglycerol biosynthetic process; cellular lipid metabolic process; long-chain fatty acid metabolic process; response to organic cyclic substance; response to nutrient; xenobiotic catabolic process
NCBI Summary:	The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
UniProt Code:	P33121
NCBI GenInfo Identifier:	417241
NCBI Gene ID:	2180
NCBI Accession:	P33121.1
UniProt Related Accession:	P33121
Molecular Weight:
NCBI Full Name:	Long-chain-fatty-acid--CoA ligase 1
NCBI Synonym Full Names:	acyl-CoA synthetase long chain family member 1
NCBI Official Symbol:	ACSL1
NCBI Official Synonym Symbols:	ACS1; LACS; FACL1; FACL2; LACS1; LACS2
NCBI Protein Information:	long-chain-fatty-acid--CoA ligase 1
UniProt Protein Name:	Long-chain-fatty-acid--CoA ligase 1
UniProt Synonym Protein Names:	Acyl-CoA synthetase 1; ACS1; Long-chain acyl-CoA synthetase 1; LACS 1; Long-chain acyl-CoA synthetase 2; LACS 2; Long-chain fatty acid-CoA ligase 2; Palmitoyl-CoA ligase 1; Palmitoyl-CoA ligase 2
Protein Family:	Long-chain-fatty-acid--CoA ligase
UniProt Gene Name:	ACSL1
UniProt Entry Name:	ACSL1_HUMAN