Cell Biology Antibodies 15
Anti-ACR Antibody (CAB18631)
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- SKU:
- CAB18631
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ACR Antibody |
| Antibody SKU: | CAB18631 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACR (NP_001088.2). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACR (NP_001088.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 49 |
| Uniprot: | P10323 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | |
| Background: |
| UniProt Protein Function: | ACR: Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Belongs to the peptidase S1 family. |
| UniProt Protein Details: | Protein type:EC 3.4.21.10; Protease Chromosomal Location of Human Ortholog: 22q13.33 Cellular Component: acrosomal matrix; extracellular region; nucleus; protein complex Molecular Function:amidase activity; drug binding; fucose binding; mannose binding; protease binding; protein binding; serine-type endopeptidase activity Biological Process: acrosome reaction; adenylate cyclase activation; penetration of zona pellucida; single fertilization |
| NCBI Summary: | Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P10323 |
| NCBI GenInfo Identifier: | 115502349 |
| NCBI Gene ID: | 49 |
| NCBI Accession: | P10323.4 |
| UniProt Secondary Accession: | P10323,Q6ICK2, |
| UniProt Related Accession: | P10323 |
| Molecular Weight: | 45,847 Da |
| NCBI Full Name: | Acrosin |
| NCBI Synonym Full Names: | acrosin |
| NCBI Official Symbol: | ACR |
| NCBI Protein Information: | acrosin |
| UniProt Protein Name: | Acrosin |
| Protein Family: | Acrosin |
| UniProt Gene Name: | ACR |
| UniProt Entry Name: | ACRO_HUMAN |
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