Metabolism Antibodies 1
Anti-ACOT2 Antibody (CAB14390)
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- SKU:
- CAB14390
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ACOT2 Antibody |
| Antibody SKU: | CAB14390 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 222-483 of human ACOT2 (NP_006812.3). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | 293T, LO2, U-87MG, Mouse kidney |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 222-483 of human ACOT2 (NP_006812.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IVDM FGTG GGLL EYRA SLLA GKGF AVMA LAYY NYED LPKT METL HLEY FEEA MNYL LSHP EVKG PGVG LLGI SKGG ELCL SMAS FLKG ITAA VVIN GSVA NVGG TLHY KGET LPPV GVNR NRIK VTKD GYAD IVDV LNSP LEGP DQKS FIPV ERAE STFL FLVG QDDH NWKS EFYA NEAC KRLQ AHGR RKPQ IICY PETG HYIE PPYF PLCR ASLH ALVG SPII WGGE PRAH AMAQ VDAW KQLQ TFFH KHLG GHEG TIPS KV |
| Gene ID: | 10965 |
| Uniprot: | P49753 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 32kDa/53kDa |
| Observed MW: | 50kDa |
| Synonyms: | ACOT2, CTE-IA, CTE1A, MTE1, PTE2, PTE2A, ZAP128 |
| Background: | This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. |
| UniProt Protein Function: | ACOT2: Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. Displays high levels of activity on medium- and long chain acyl CoAs. Belongs to the C/M/P thioester hydrolase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Mitochondrial; Hydrolase; Lipid Metabolism - unsaturated fatty acid biosynthesis; EC 3.1.2.2 Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: mitochondrion Molecular Function:acyl-CoA hydrolase activity; palmitoyl-CoA hydrolase activity; receptor binding Biological Process: acyl-CoA metabolic process; very-long-chain fatty acid metabolic process; long-chain fatty acid metabolic process |
| NCBI Summary: | This gene encodes a member of the acyl-CoA thioesterase protein family, and is one of four acyl-CoA hydrolase genes located in a cluster on chromosome 14. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| UniProt Code: | P49753 |
| NCBI GenInfo Identifier: | 269849771 |
| NCBI Gene ID: | 10965 |
| NCBI Accession: | P49753.6 |
| UniProt Secondary Accession: | P49753,Q3I5F8, Q53EK4, Q9NUX4, |
| UniProt Related Accession: | P49753 |
| Molecular Weight: | 32,959 Da |
| NCBI Full Name: | Acyl-coenzyme A thioesterase 2, mitochondrial |
| NCBI Synonym Full Names: | acyl-CoA thioesterase 2 |
| NCBI Official Symbol: | ACOT2 |
| NCBI Official Synonym Symbols: | MTE1; PTE2; CTE1A; PTE2A; CTE-IA; ZAP128 |
| NCBI Protein Information: | acyl-coenzyme A thioesterase 2, mitochondrial; long-chain acyl-CoA thioesterase 2; mitochondrial acyl-CoA thioesterase 1; acyl-coenzyme A thioester hydrolase 2a; peroxisomal long-chain acyl-coA thioesterase 2 |
| UniProt Protein Name: | Acyl-coenzyme A thioesterase 2, mitochondrial |
| UniProt Synonym Protein Names: | Acyl-coenzyme A thioester hydrolase 2a; CTE-Ia; Long-chain acyl-CoA thioesterase 2; ZAP128 |
| Protein Family: | Acyl-CoA thioesterase |
| UniProt Gene Name: | ACOT2 |
| UniProt Entry Name: | ACOT2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACOT2 antibody (CAB14390) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s. |
 | Immunohistochemistry of paraffin-embedded human appendix using ACOT2 antibody (CAB14390) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using ACOT2 antibody (CAB14390) at dilution of 1:100 (40x lens). |
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