Signal Transduction Antibodies 2

Anti-ACMSD Antibody (CAB15953)

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SKU:
CAB15953
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ACMSD Antibody
Antibody SKU:CAB15953
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Mouse liver, Rat kidney
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-336 of human ACMSD (NP_612199.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKID IHSH ILPK EWPD LKKR FGYG GWVQ LQHH SKGE AKLL KDGK VFRV VREN CWDP EVRI REMD QKGV TVQA LSTV PVMF SYWA KPED TLNL CQLL NNDL ASTV VSYP RRFV GLGT LPMQ APEL AVKE MERC VKEL GFPG VQIG THVN EWDL NAQE LFPV YAAA ERLK CSLF VHPW DMQM DGRM AKYW LPWL VGMP AETT IAIC SMIM GGVF EKFP KLKV CFAH GGGA FPFT VGRI SHGF SMRP DLCA QDNP MNPK KYLG SFYT DALV HDPL SLKL LTDV IGKD KVIL GTDY PFPL GELE PGKL IESM EEFD EETK NKLK AGNA LAFL GLER KQFE
Gene ID:130013
Uniprot:Q8TDX5
Cellular Location:
Calculated MW:31kDa/38kDa
Observed MW:38kDa
Synonyms:ACMSD
Background:The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.
UniProt Protein Function:ACMSD: Converts alpha-amino-beta-carboxymuconate-epsilon- semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway. Belongs to the ACMSD family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 4.1.1.45; Amino Acid Metabolism - tryptophan; Lyase

Chromosomal Location of Human Ortholog: 2q21.3

Cellular Component: cytosol

Molecular Function:aminocarboxymuconate-semialdehyde decarboxylase activity; metal ion binding

Biological Process: quinolinate metabolic process; tryptophan catabolic process

NCBI Summary:The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
UniProt Code:Q8TDX5
NCBI GenInfo Identifier:37999723
NCBI Gene ID:130013
NCBI Accession:Q8TDX5.1
UniProt Secondary Accession:Q8TDX5,Q3B7X3, Q53SR5, Q96KY2,
UniProt Related Accession:Q8TDX5
Molecular Weight:31,213 Da
NCBI Full Name:2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
NCBI Synonym Full Names:aminocarboxymuconate semialdehyde decarboxylase
NCBI Official Symbol:ACMSD  
NCBI Protein Information:2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase
UniProt Protein Name:2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
UniProt Synonym Protein Names:Picolinate carboxylase
Protein Family:2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
UniProt Gene Name:ACMSD  
UniProt Entry Name:ACMSD_HUMAN
Anti-ACMSD Antibody (CAB15953)Western blot analysis of extracts of various cell lines, using ACMSD antibody (CAB15953) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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