Cell Biology Antibodies 3

Anti-ACKR3 Antibody (CAB12712)

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SKU:
CAB12712
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ACKR3 Antibody
Antibody SKU:CAB12712
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACKR3 (NP_064707.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:4T1, Mouse brain, Mouse lung
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ACKR3 (NP_064707.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:IYIF IFVI GMIA NSVV VWVN IQAK TTGY DTHC YILN LAIA DLWV VLTI PVWV VSLV QHNQ WPMG ELTC KVTH LIFS INLF GSIF FLTC MSVD RYLS ITYF T
Gene ID:57007
Uniprot:P25106
Cellular Location:Cell membrane, Cytoplasm, Early endosome, Multi-pass membrane protein, Recycling endosome, perinuclear region
Calculated MW:41kDa
Observed MW:44KDa
Synonyms:ACKR3, CMKOR1, CXC-R7, CXCR-7, CXCR7, GPR159, RDC-1, RDC1
Background:This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas.
UniProt Protein Function:CMKOR1: Receptor for chemokines CXCL12/SDF1 and CXCL11. Does not elicit classical chemokine receptor signaling; chemokine binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization and activation of MAPK signaling pathway. Acts as a scavenger for CXCL12/SDF1 and, to a lesser extent, for CXCL11. Required for regulation of CXCR4 protein levels in migrating interneurons, thereby adapting their chemokine responsiveness. In glioma cells, transduces signals via MEK/ERK pathway, mediating resistance to apoptosis. Promotes cell growth and survival. Not involved in cell migration, adhesion or proliferation of normal hematopoietic progenitors but activated by CXCL11 in malignant hemapoietic cells, leading to phosphorylation of ERK1/2 (MAPK3/MAPK1) and enhanced cell adhesion and migration. Plays a regulatory role in CXCR4-mediated activation of cell surface integrins by CXCL12. Required for heart valve development. Acts as coreceptor with CXCR4 for a restricted number of HIV isolates. Belongs to the G-protein coupled receptor 1 family.
UniProt Protein Details:

Protein type:GPCR, family 1; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR

Chromosomal Location of Human Ortholog: 2q37.3

Cellular Component: cell surface; coated pit; endosome; intracellular membrane-bound organelle; plasma membrane

Molecular Function:C-X-C chemokine binding; C-X-C chemokine receptor activity; protein binding; scavenger receptor activity

Biological Process: receptor internalization

NCBI Summary:This gene encodes a member of the G-protein coupled receptor family. Although this protein was earlier thought to be a receptor for vasoactive intestinal peptide (VIP), it is now considered to be an orphan receptor, in that its endogenous ligand has not been identified. The protein is also a coreceptor for human immunodeficiency viruses (HIV). Translocations involving this gene and HMGA2 on chromosome 12 have been observed in lipomas. [provided by RefSeq, Jul 2008]
UniProt Code:P25106
NCBI GenInfo Identifier:115502380
NCBI Gene ID:57007
NCBI Accession:P25106.3
UniProt Secondary Accession:P25106,Q53RV4, Q8NE10, Q92938, Q92986, A8K6J4,
UniProt Related Accession:P25106
Molecular Weight:41,493 Da
NCBI Full Name:Atypical chemokine receptor 3
NCBI Synonym Full Names:atypical chemokine receptor 3
NCBI Official Symbol:ACKR3  
NCBI Official Synonym Symbols:RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159  
NCBI Protein Information:atypical chemokine receptor 3
UniProt Protein Name:Atypical chemokine receptor 3
UniProt Synonym Protein Names:C-X-C chemokine receptor type 7; CXC-R7; CXCR-7; Chemokine orphan receptor 1; G-protein coupled receptor 159; G-protein coupled receptor RDC1 homolog; RDC-1
Protein Family:Non-reducing polyketide synthase
UniProt Gene Name:ACKR3  
Anti-ACKR3 Antibody (CAB12712)Western blot analysis of extracts of various cell lines, using ACKR3 Rabbit pAb (CAB12712) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.
Anti-ACKR3 Antibody (CAB12712)Immunofluorescence analysis of Mouse skin using ACKR3 Rabbit pAb (CAB12712) at dilution of 1:100. Blue: DAPI for nuclear staining.
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