Description
| Product Name: | ACE2 Rabbit mAb |
| Product Code: | CAB4612 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ACEH |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ACE2 |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse brain, Mouse heart, Rat brain, Rat kidney |
| Immunogen: | A synthesized peptide derived from human ACE2 |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 59272 |
| Uniprot: | Q9BYF1 |
| Cellular Location: | Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 92kDa |
| Observed MW: | 100KDa/120KDa |
| UniProt Protein Function: | ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.17.23; Protease Chromosomal Location of Human Ortholog: Xp22 Cellular Component: cell surface; extracellular region; extracellular space; lipid raft; plasma membrane Molecular Function:carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidyl-dipeptidase activity; protein binding; viral receptor activity; zinc ion binding Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated drinking behavior; entry of virus into host cell; receptor biosynthetic process; regulation of cell proliferation; regulation of cytokine production; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; virion attachment, binding of host cell surface receptor |
| NCBI Summary: | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYF1 |
| NCBI GenInfo Identifier: | 71658783 |
| NCBI Gene ID: | 59272 |
| NCBI Accession: | Q9BYF1.2 |
| UniProt Secondary Accession: | Q9BYF1,Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6, C7ECU1, |
| UniProt Related Accession: | Q9BYF1 |
| Molecular Weight: | 63,912 Da |
| NCBI Full Name: | Angiotensin-converting enzyme 2 |
| NCBI Synonym Full Names: | angiotensin I converting enzyme 2 |
| NCBI Official Symbol: | ACE2 |
| NCBI Official Synonym Symbols: | ACEH |
| NCBI Protein Information: | angiotensin-converting enzyme 2 |
| UniProt Protein Name: | Angiotensin-converting enzyme 2 |
| UniProt Synonym Protein Names: | ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH |
| Protein Family: | Angiotensin-converting enzyme |
| UniProt Gene Name: | ACE2 |
| UniProt Entry Name: | ACE2_HUMAN |
