Immunology Antibodies 1
Anti-ACE2 Antibody (CAB12737)
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- SKU:
- CAB12737
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Immunology
Description
| Antibody Name: | Anti-ACE2 Antibody |
| Antibody SKU: | CAB12737 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-250 of human ACE2 (NP_068576.1). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HepG2, Mouse brain, Mouse kidney, Rat brain |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 18-250 of human ACE2 (NP_068576.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | QSTI EEQA KTFL DKFN HEAE DLFY QSSL ASWN YNTN ITEE NVQN MNNA GDKW SAFL KEQS TLAQ MYPL QEIQ NLTV KLQL QALQ QNGS SVLS EDKS KRLN TILN TMST IYST GKVC NPDN PQEC LLLE PGLN EIMA NSLD YNER LWAW ESWR SEVG KQLR PLYE EYVV LKNE MARA NHYE DYGD YWRG DYEV NGVD GYDY SRGQ LIED VEHT FEEI KPLY EHLH AYVR AKLM N |
| Gene ID: | 59272 |
| Uniprot: | Q9BYF1 |
| Cellular Location: | Cell membrane, Cytoplasm, Secreted, Single-pass type I membrane protein |
| Calculated MW: | 63kDa/92kDa |
| Observed MW: | 135KDa/100KDa |
| Synonyms: | ACE2, ACEH |
| Background: | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. |
| UniProt Protein Function: | ACE2: Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin- 13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses. Interacts with ITGB1. Interacts with SARS-CoV and HCoV- NL63 spike glycoprotein. Up-regulated in failing heart. Expressed in endothelial cells from small and large arteries, and in arterial smooth muscle cells. Expressed in lung alveolar epithelial cells, enterocytes of the small intestine, Leydig cells and Sertoli cells. Expressed in heart, kidney, testis, and gastrointestinal system. Activated by chloride and fluoride, but not bromide. Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. Belongs to the peptidase M2 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; EC 3.4.17.23; Protease Chromosomal Location of Human Ortholog: Xp22 Cellular Component: cell surface; extracellular region; extracellular space; lipid raft; plasma membrane Molecular Function:carboxypeptidase activity; endopeptidase activity; glycoprotein binding; metallocarboxypeptidase activity; metallopeptidase activity; peptidyl-dipeptidase activity; protein binding; viral receptor activity; zinc ion binding Biological Process: angiotensin catabolic process in blood; angiotensin maturation; angiotensin mediated drinking behavior; entry of virus into host cell; receptor biosynthetic process; regulation of cell proliferation; regulation of cytokine production; regulation of inflammatory response; regulation of systemic arterial blood pressure by renin-angiotensin; regulation of vasoconstriction; regulation of vasodilation; virion attachment, binding of host cell surface receptor |
| NCBI Summary: | The protein encoded by this gene belongs to the angiotensin-converting enzyme family of dipeptidyl carboxydipeptidases and has considerable homology to human angiotensin 1 converting enzyme. This secreted protein catalyzes the cleavage of angiotensin I into angiotensin 1-9, and angiotensin II into the vasodilator angiotensin 1-7. The organ- and cell-specific expression of this gene suggests that it may play a role in the regulation of cardiovascular and renal function, as well as fertility. In addition, the encoded protein is a functional receptor for the spike glycoprotein of the human coronaviruses SARS and HCoV-NL63. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q9BYF1 |
| NCBI GenInfo Identifier: | 71658783 |
| NCBI Gene ID: | 59272 |
| NCBI Accession: | Q9BYF1.2 |
| UniProt Secondary Accession: | Q9BYF1,Q6UWP0, Q86WT0, Q9NRA7, Q9UFZ6, C7ECU1, |
| UniProt Related Accession: | Q9BYF1 |
| Molecular Weight: | 63,912 Da |
| NCBI Full Name: | Angiotensin-converting enzyme 2 |
| NCBI Synonym Full Names: | angiotensin I converting enzyme 2 |
| NCBI Official Symbol: | ACE2Â Â |
| NCBI Official Synonym Symbols: | ACEHÂ Â |
| NCBI Protein Information: | angiotensin-converting enzyme 2 |
| UniProt Protein Name: | Angiotensin-converting enzyme 2 |
| UniProt Synonym Protein Names: | ACE-related carboxypeptidase; Angiotensin-converting enzyme homolog; ACEH |
| Protein Family: | Angiotensin-converting enzyme |
| UniProt Gene Name: | ACE2Â Â |
| UniProt Entry Name: | ACE2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACE2 antibody (CAB12737) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s. |
 | Western blot analysis of extracts of HepG2 cells, using ACE2 antibody (CAB12737) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 180s. |
 | Immunohistochemistry of paraffin-embedded rat lung using ACE2 Rabbit pAb (CAB12737) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using ACE2 Rabbit pAb (CAB12737) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using ACE2 Rabbit pAb (CAB12737) at dilution of 1:100 (40x lens). |
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