Cell Biology Antibodies 2

Anti-ACD Antibody (CAB12177)

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SKU:
CAB12177
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ACD Antibody
Antibody SKU:CAB12177
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, Mouse liver, Mouse spleen, Mouse testis, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MPGR CQSD AAMR VNGP ASRA PAGW TSGS LHTG PRAG RPRA QARG VRGR GLLL RPRP AKEL PLPR KGGA WAPA GNPG PLHP LGVA VGMA GSGR LVLR PWIR ELIL GSET PSSP RAGQ LLEV LQDA EAAV AGPS HAPD TSDV GATL LVSD GTHS VRCL VTRE ALDT SDWE EKEF GFRG TEGR LLLL QDCG VHVQ VAEG GAPA EFYL QVDR FSLL PTEQ PRLR
Gene ID:65057
Uniprot:Q96AP0
Cellular Location:Chromosome, Nucleus, telomere
Calculated MW:57kDa
Observed MW:58kDa
Synonyms:ACD, PIP1, PTOP, TINT1, TPP1
Background:This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I.
UniProt Protein Function:ACD: Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends; without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by increasing telomerase processivity. Plays a role in shelterin complex assembly. May play a role in organogenesis. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 16q22.1

Cellular Component: nuclear body; nuclear chromosome, telomeric region; nuclear telomere cap complex; nucleoplasm

Molecular Function:protein binding; telomeric DNA binding

Biological Process: intracellular protein transport; negative regulation of telomere maintenance via telomerase; positive regulation of telomerase activity; positive regulation of telomere maintenance via telomerase; protection from non-homologous end joining at telomere; telomere assembly; telomere capping; telomere maintenance

Disease: Dyskeratosis Congenita, Autosomal Dominant 6

NCBI Summary:This gene encodes a protein that is involved in telomere function. This protein is one of six core proteins in the telosome/shelterin telomeric complex, which functions to maintain telomere length and to protect telomere ends. Through its interaction with other components, this protein plays a key role in the assembly and stabilization of this complex, and it mediates the access of telomerase to the telomere. Multiple transcript variants encoding different isoforms have been found for this gene. This gene, which is also referred to as TPP1, is distinct from the unrelated TPP1 gene on chromosome 11, which encodes tripeptidyl-peptidase I. [provided by RefSeq, Jul 2008]
UniProt Code:Q96AP0
NCBI GenInfo Identifier:296439451
NCBI Gene ID:65057
NCBI Accession:Q96AP0.3
UniProt Secondary Accession:Q96AP0,Q562H5, Q9H8F9,
UniProt Related Accession:Q96AP0
Molecular Weight:58kDa
NCBI Full Name:Adrenocortical dysplasia protein homolog
NCBI Synonym Full Names:ACD, shelterin complex subunit and telomerase recruitment factor
NCBI Official Symbol:ACD  
NCBI Official Synonym Symbols:PIP1; PTOP; TPP1; TINT1  
NCBI Protein Information:adrenocortical dysplasia protein homolog
UniProt Protein Name:Adrenocortical dysplasia protein homolog
UniProt Synonym Protein Names:POT1 and TIN2-interacting protein
Protein Family:ACD11 homolog protein
UniProt Gene Name:ACD  
Anti-ACD Antibody (CAB12177)Western blot analysis of extracts of various cell lines, using ACD antibody (CAB12177) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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