Autophagy Antibodies

Anti-ACBD5 Antibody (CAB10595)

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SKU:
CAB10595
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Autophagy

Description

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Antibody Name:Anti-ACBD5 Antibody
Antibody SKU:CAB10595
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-440 of human ACBD5 (NP_663736.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human
Positive Samples:HeLa, LO2, Jurkat, A-549, MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 170-440 of human ACBD5 (NP_663736.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:TSTP NAKT VNGK AESS DSGA ESEE EEAQ EEVK GAEQ SDND KKMM KKSA DHKN LEVI VTNG YDKD GFVQ DIQN DIHA SSSL NGRS TEEV KPID ENLG QTGK SAVC IHQD INDD HVED VTGI QHLT SDSD SEVY CDSM EQFG QEES LDSF TSNN GPFQ YYLG GHSS QPME NSGF REDI QVPP GNGN IGNM QVVA VEGK GEVK HGGE DGRN NSGA PHRE KRGG ETDE FSNV RRGR GHRM QHLS EGTK GRQV GSGG DGER WGSD RGSR GSLN EQI
Gene ID:91452
Uniprot:Q5T8D3
Cellular Location:Peroxisome membrane, Single-pass membrane protein
Calculated MW:46kDa/54kDa/58kDa/60kDa
Observed MW:70kDa
Synonyms:ACBD5
Background:This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ACBD5: Binds medium- and long-chain acyl-CoA esters. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Lipid-binding; Membrane protein, integral

Chromosomal Location of Human Ortholog: 10p12.1

Cellular Component: membrane; nucleoplasm; nucleus; peroxisomal membrane; peroxisome

Biological Process: cellular lipid metabolic process; macroautophagy; peroxisome degradation

NCBI Summary:This gene encodes a member of the acyl-Coenzyme A binding protein family, known to function in the transport and distribution of long chain acyl-Coenzyme A in cells. This gene may play a role in the differentiation of megakaryocytes and formation of platelets. A related protein in yeast is involved in autophagy of peroxisomes. A mutation in this gene has been associated with autosomal dominant thrombocytopenia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]
UniProt Code:Q5T8D3
NCBI GenInfo Identifier:74745508
NCBI Gene ID:91452
NCBI Accession:Q5T8D3.1
UniProt Secondary Accession:Q5T8D3,Q5T8D4, Q5T8E1, Q5T8E2, Q86UV1, Q8N6E3, Q9UFB5 B3KQ56, D3DRW0,
UniProt Related Accession:Q5T8D3
Molecular Weight:60kDa
NCBI Full Name:Acyl-CoA-binding domain-containing protein 5
NCBI Synonym Full Names:acyl-CoA binding domain containing 5
NCBI Official Symbol:ACBD5  
NCBI Protein Information:acyl-CoA-binding domain-containing protein 5
UniProt Protein Name:Acyl-CoA-binding domain-containing protein 5
Protein Family:Acyl-CoA-binding domain-containing protein
UniProt Gene Name:ACBD5  
Anti-ACBD5 Antibody (CAB10595)Western blot analysis of extracts of various cell lines, using ACBD5 antibody (CAB10595) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
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