Cell Biology Antibodies 11
Anti-ACAT2 Antibody (CAB7866)
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- SKU:
- CAB7866
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ACAT2 Antibody |
| Antibody SKU: | CAB7866 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human ACAT2 (NP_005882.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | BT-474, MCF7, HeLa, HepG2, PC-12, Mouse liver |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-97 of human ACAT2 (NP_005882.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MNAG SDPV VIVS AART IIGS FNGA LAAV PVQD LGST VIKE VLKR ATVA PEDV SEVI FGHV LAAG CGQN PVRQ ASVG AGIP YSVP AWSC QMIC GSGL K |
| Gene ID: | 39 |
| Uniprot: | Q9BWD1 |
| Cellular Location: | Cytoplasm |
| Calculated MW: | 41kDa/44kDa |
| Observed MW: | 41kDa |
| Synonyms: | ACAT2 |
| Background: | The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ACAT2: The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Carbohydrate Metabolism - butanoate; Lipid Metabolism - synthesis and degradation of ketone bodies; Carbohydrate Metabolism - pyruvate; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Amino Acid Metabolism - tryptophan; Acetyltransferase; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Carbohydrate Metabolism - propanoate; EC 2.3.1.9; Lipid Metabolism - fatty acid; Amino Acid Metabolism - lysine degradation Chromosomal Location of Human Ortholog: 6q25.3 Cellular Component: nucleoplasm; cytoplasm; nucleolus; nucleus Molecular Function:acetyl-CoA C-acetyltransferase activity Biological Process: lipid metabolic process Disease: Acetyl-coa Acetyltransferase-2 Deficiency |
| NCBI Summary: | The product of this gene is an enzyme involved in lipid metabolism, and it encodes cytosolic acetoacetyl-CoA thiolase. This gene shows complementary overlapping with the 3-prime region of the TCP1 gene in both mouse and human. These genes are encoded on opposite strands of DNA, as well as in opposite transcriptional orientation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014] |
| UniProt Code: | Q9BWD1 |
| NCBI GenInfo Identifier: | 52000838 |
| NCBI Gene ID: | 39 |
| NCBI Accession: | Q9BWD1.2 |
| UniProt Related Accession: | Q9BWD1 |
| Molecular Weight: | 41 kDa |
| NCBI Full Name: | Acetyl-CoA acetyltransferase, cytosolic |
| NCBI Synonym Full Names: | acetyl-CoA acetyltransferase 2 |
| NCBI Official Symbol: | ACAT2 |
| NCBI Protein Information: | acetyl-CoA acetyltransferase, cytosolic |
| UniProt Protein Name: | Acetyl-CoA acetyltransferase, cytosolic |
| UniProt Synonym Protein Names: | Acetyl-CoA transferase-like protein; Cytosolic acetoacetyl-CoA thiolase |
| Protein Family: | Acetyl-CoA acetyltransferase |
| UniProt Gene Name: | ACAT2 |
| UniProt Entry Name: | THIC_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ACAT2 antibody (CAB7866) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat ovary using ACAT2 antibody (CAB7866) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human colon carcinoma using ACAT2 antibody (CAB7866) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human oophoroma using ACAT2 antibody (CAB7866) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse kidney using ACAT2 antibody (CAB7866) at dilution of 1:100 (40x lens). |
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