Cell Biology Antibodies 6

Anti-ACAP1 Antibody (CAB15614)

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SKU:
CAB15614
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ACAP1 Antibody
Antibody SKU:CAB15614
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 20-230 of human ACAP1 (NP_055531.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:SIEL VEAE VSEL ETRL EKLL KLGT GLLE SGRH YLAA SRAF VVGI CDLA RLGP PEPM MAEC LEKF TVSL NHKL DSHA ELLD ATQH TLQQ QIQT LVKE GLRG FREA RRDF WRGA ESLE AALT HNAE VPRR RAQE AEEA GAAL RTAR AGYR GRAL DYAL QINV IEDK RKFD IMEF VLRL VEAQ ATHF QQGH EELS RLSQ YRKE LGAQ LHQL VLN
Gene ID:9744
Uniprot:Q15027
Cellular Location:
Calculated MW:81kDa
Observed MW:Refer to figures
Synonyms:ACAP1, CENTB1
Background:
UniProt Protein Function:CENTB1: a member of the centaurin family of ADP-ribosylation factor directed GTPase-activating proteins (GAPs). A GAP for ARF1 and ARF5. Two alternatively-spliced isoforms have been described. Isoform 1 is brain-specific, and isoform 2 is ubiquitously expressed, with highest levels in brain and heart. Isoform 1 participates to the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. Regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. The PH domains of isoforms 1 and 2 bind phospholipids, but they differentially regulate subcellular location. The PH domain of isoform 1 directs the protein to the nucleus, but the PH domain of isoform 2 directs it to the cytosol.
UniProt Protein Details:

Protein type:GAPs, ARF; GAPs; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 17p13.1

Cellular Component: membrane

Molecular Function:protein binding

UniProt Code:Q15027
NCBI GenInfo Identifier:3183210
NCBI Gene ID:9744
NCBI Accession:Q15027.1
UniProt Secondary Accession:Q15027,Q53XN9,
UniProt Related Accession:Q15027
Molecular Weight:81,536 Da
NCBI Full Name:Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
NCBI Synonym Full Names:ArfGAP with coiled-coil, ankyrin repeat and PH domains 1
NCBI Official Symbol:ACAP1  
NCBI Official Synonym Symbols:CENTB1  
NCBI Protein Information:arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Protein Name:Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 1
UniProt Synonym Protein Names:Centaurin-beta-1; Cnt-b1
Protein Family:Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein
UniProt Gene Name:ACAP1  
UniProt Entry Name:ACAP1_HUMAN
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