Metabolism Antibodies 3
Anti-ACADM Antibody (CAB4567)
- SKU:
- CAB4567
- Product Type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACAD1
- Synonyms:
- MCAD
- Synonyms:
- MCADH
- Research Area:
- Metabolism
Description
| Product Name: | ACADM Rabbit mAb |
| Product Code: | CAB4567 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | ACAD1, MCAD, MCADH |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human ACADM |
| Applications: | WB, IHC, IF |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, 293T, HepG2, Mouse liver, Mouse heart, Rat liver, Rat heart |
| Immunogen: | A synthesized peptide derived from human ACADM |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 34 |
| Uniprot: | P11310 |
| Calculated MW: | 46kDa |
| Observed MW: | 45KDa |
| UniProt Protein Function: | ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.3.8.7; Mitochondrial; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine Chromosomal Location of Human Ortholog: 1p31 Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus Molecular Function:acyl-CoA dehydrogenase activity; identical protein binding; FAD binding Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of |
| NCBI Summary: | This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11310 |
| NCBI GenInfo Identifier: | 113017 |
| NCBI Gene ID: | 34 |
| NCBI Accession: | P11310.1 |
| UniProt Related Accession: | P11310 |
| Molecular Weight: | |
| NCBI Full Name: | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| NCBI Synonym Full Names: | acyl-CoA dehydrogenase medium chain |
| NCBI Official Symbol: | ACADM |
| NCBI Official Synonym Symbols: | MCAD; ACAD1; MCADH |
| NCBI Protein Information: | medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| UniProt Protein Name: | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| UniProt Gene Name: | ACADM |
| UniProt Entry Name: | ACADM_HUMAN |
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