Metabolism Antibodies 2

Anti-ACADM Antibody (CAB1873)

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SKU:
CAB1873
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Metabolism

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ACADM Antibody
Antibody SKU:CAB1873
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACADM (NP_000007.1).
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, HepG2, U-251MG, K-562, Mouse liver, Mouse kidney, Mouse brain, Mouse heart, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACADM (NP_000007.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MAAG FGRC CRVL RSIS RFHW RSQH TKAN RQRE PGLG FSFE FTEQ QKEF QATA RKFA REEI IPVA AEYD KTGE YPVP LIRR AWEL GLMN THIP ENCG GLGL GTFD ACLI SEEL AYGC TGVQ TAIE GNSL GQMP IIIA GNDQ QKKK YLGR MTEE PLMC AYCV TEPG AGSD VAGI KTKA EKKG DEYI INGQ KMWI TNGG KANW YFLL ARSD PDPK APAN KAFT
Gene ID:34
Uniprot:P11310
Cellular Location:Mitochondrion matrix
Calculated MW:46kDa/47kDa
Observed MW:46kDa
Synonyms:ACADM, ACAD1, MCAD, MCADH
Background:This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
UniProt Protein Function:ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 1.3.8.7; Mitochondrial; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine

Chromosomal Location of Human Ortholog: 1p31

Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus

Molecular Function:acyl-CoA dehydrogenase activity; identical protein binding; FAD binding

Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process

Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of

NCBI Summary:This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P11310
NCBI GenInfo Identifier:113017
NCBI Gene ID:34
NCBI Accession:P11310.1
UniProt Related Accession:P11310
Molecular Weight:
NCBI Full Name:Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
NCBI Synonym Full Names:acyl-CoA dehydrogenase medium chain
NCBI Official Symbol:ACADM  
NCBI Official Synonym Symbols:MCAD; ACAD1; MCADH  
NCBI Protein Information:medium-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Protein Name:Medium-chain specific acyl-CoA dehydrogenase, mitochondrial
UniProt Gene Name:ACADM  
UniProt Entry Name:ACADM_HUMAN
Anti-ACADM Antibody (CAB1873)Western blot analysis of extracts of various cell lines, using ACADM antibody (CAB1873) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-ACADM Antibody (CAB1873)Immunofluorescence analysis of HeLa cells using ACADM antibody (CAB1873) at dilution of 1:100 (40x lens). Blue: DAPI for nuclear staining.
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