Metabolism Antibodies 3
Anti-ACADM Antibody (CAB13940)
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- SKU:
- CAB13940
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Description
| Antibody Name: | Anti-ACADM Antibody |
| Antibody SKU: | CAB13940 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-421 of human ACADM (NP_000007.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:100 |
| Reactivity: | Human |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 26-421 of human ACADM (NP_000007.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | KANR QREP GLGF SFEF TEQQ KEFQ ATAR KFAR EEII PVAA EYDK TGEY PVPL IRRA WELG LMNT HIPE NCGG LGLG TFDA CLIS EELA YGCT GVQT AIEG NSLG QMPI IIAG NDQQ KKKY LGRM TEEP LMCA YCVT EPGA GSDV AGIK TKAE KKGD EYII NGQK MWIT NGGK ANWY FLLA RSDP DPKA PANK AFTG FIVE ADTP GIQI GRKE LNMG QRCS DTRG IVFE DVKV PKEN VLIG DGAG FKVA MGAF DKTR PVVA AGAV GLAQ RALD EATK YALE RKTF GKLL VEHQ AISF MLAE MAMK VELA RMSY QRAA WEVD SGRR NTYY ASIA KAFA GDIA NQLA TDAV QILG GNGF NTEY PVEK LMRD AKIY QIYE GTSQ IQRL IVAR EHID KYKN |
| Gene ID: | 34 |
| Uniprot: | P11310 |
| Cellular Location: | Mitochondrion matrix |
| Calculated MW: | 46kDa/47kDa |
| Observed MW: |
 | Immunohistochemistry - ACADM Polyclonal Antibody (CAB13940) |
| Synonyms: | ACADM, ACAD1, MCAD, MCADH |
| Background: | This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. |
| UniProt Protein Function: | ACADM: This enzyme is specific for acyl chain lengths of 4 to 16. Defects in ACADM are the cause of acyl-CoA dehydrogenase medium-chain deficiency (ACADMD). It is an autosomal recessive disease which causes fasting hypoglycemia, hepatic dysfunction, and encephalopathy, often resulting in death in infancy. Belongs to the acyl-CoA dehydrogenase family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.3.8.7; Mitochondrial; Carbohydrate Metabolism - propanoate; Oxidoreductase; Lipid Metabolism - fatty acid; Amino Acid Metabolism - valine, leucine and isoleucine degradation; Other Amino Acids Metabolism - beta-alanine Chromosomal Location of Human Ortholog: 1p31 Cellular Component: mitochondrion; axon; mitochondrial matrix; nucleus Molecular Function:acyl-CoA dehydrogenase activity; identical protein binding; FAD binding Biological Process: carnitine metabolic process, CoA-linked; fatty acid beta-oxidation; medium-chain fatty acid catabolic process; cellular lipid metabolic process; medium-chain fatty acid metabolic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; carnitine biosynthetic process Disease: Acyl-coa Dehydrogenase, Medium-chain, Deficiency Of |
| NCBI Summary: | This gene encodes the medium-chain specific (C4 to C12 straight chain) acyl-Coenzyme A dehydrogenase. The homotetramer enzyme catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. Defects in this gene cause medium-chain acyl-CoA dehydrogenase deficiency, a disease characterized by hepatic dysfunction, fasting hypoglycemia, and encephalopathy, which can result in infantile death. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P11310 |
| NCBI GenInfo Identifier: | 113017 |
| NCBI Gene ID: | 34 |
| NCBI Accession: | P11310.1 |
| UniProt Related Accession: | P11310 |
| Molecular Weight: | |
| NCBI Full Name: | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| NCBI Synonym Full Names: | acyl-CoA dehydrogenase medium chain |
| NCBI Official Symbol: | ACADM |
| NCBI Official Synonym Symbols: | MCAD; ACAD1; MCADH |
| NCBI Protein Information: | medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| UniProt Protein Name: | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial |
| UniProt Gene Name: | ACADM |
| UniProt Entry Name: | ACADM_HUMAN |
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