Metabolism Antibodies 2

Anti-ACAA1 Antibody (CAB7422)

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SKU:
CAB7422
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism

Description

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Antibody Name:Anti-ACAA1 Antibody
Antibody SKU:CAB7422
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-300 of human ACAA1 (NP_001598.1).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HL-60, MCF7, A-549, Jurkat
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 27-300 of human ACAA1 (NP_001598.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:LSGA PQAS AADV VVVH GRRT AICR AGRG GFKD TTPD ELLS AVMT AVLK DVNL RPEQ LGDI CVGN VLQP GAGA IMAR IAQF LSDI PETV PLST VNRQ CSSG LQAV ASIA GGIR NGSY DIGM ACGV ESMS LADR GNPG NITS RLME KEKA RDCL IPMG ITSE NVAE RFGI SREK QDTF ALAS QQKA ARAQ SKGC FQAE IVPV TTTV HDDK GTKR SITV TQDE GIRP STTM EGLA KLKP AFKK DGST TAGN SSQV SDGA AAIL LARR SKAE ELGL PI
Gene ID:30
Uniprot:P09110
Cellular Location:Peroxisome
Calculated MW:34kDa/44kDa
Observed MW:44kDa
Synonyms:ACAA1, ACAA, PTHIO, THIO
Background:This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ACAA1: an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Lipid Metabolism - unsaturated fatty acid biosynthesis; Lipid Metabolism - fatty acid; Acetyltransferase; EC 2.3.1.16; Amino Acid Metabolism - valine, leucine and isoleucine degradation

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: peroxisomal matrix; membrane; intracellular membrane-bound organelle; peroxisome

Molecular Function:palmitoyl-CoA oxidase activity; protein binding; acetyl-CoA C-acyltransferase activity

Biological Process: fatty acid beta-oxidation using acyl-CoA oxidase; fatty acid beta-oxidation; very-long-chain fatty acid metabolic process; bile acid metabolic process; unsaturated fatty acid metabolic process; cellular lipid metabolic process

Disease: D-bifunctional Protein Deficiency

NCBI Summary:This gene encodes an enzyme operative in the beta-oxidation system of the peroxisomes. Deficiency of this enzyme leads to pseudo-Zellweger syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
UniProt Code:P09110
NCBI GenInfo Identifier:135751
NCBI Gene ID:30
NCBI Accession:P09110.2
UniProt Secondary Accession:P09110,Q96CA6, G5E935,
UniProt Related Accession:P09110
Molecular Weight:424
NCBI Full Name:3-ketoacyl-CoA thiolase, peroxisomal
NCBI Synonym Full Names:acetyl-CoA acyltransferase 1
NCBI Official Symbol:ACAA1  
NCBI Official Synonym Symbols:ACAA; THIO; PTHIO  
NCBI Protein Information:3-ketoacyl-CoA thiolase, peroxisomal; beta-ketothiolase; peroxisomal 3-oxoacyl-CoA thiolase; acetyl-Coenzyme A acyltransferase 1; peroxisomal 3-oxoacyl-Coenzyme A thiolase
UniProt Protein Name:3-ketoacyl-CoA thiolase, peroxisomal
UniProt Synonym Protein Names:Acetyl-CoA acyltransferase; Beta-ketothiolase; Peroxisomal 3-oxoacyl-CoA thiolase
UniProt Gene Name:ACAA1  
UniProt Entry Name:THIK_HUMAN
Anti-ACAA1 Antibody (CAB7422)Western blot analysis of extracts of various cell lines, using ACAA1 antibody (CAB7422) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 1s.
Anti-ACAA1 Antibody (CAB7422)Immunohistochemistry of paraffin-embedded rat kidney using ACAA1 antibody (CAB7422) at dilution of 1:100 (40x lens).
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