Signal Transduction Antibodies 2

Anti-ABR Antibody (CAB15635)

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SKU:
CAB15635
Product Type:
Antibody
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ABR Antibody
Antibody SKU:CAB15635
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human ABR (NP_001243776.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse thymus, Rat lung, Rat spleen
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 200 to the C-terminus of human ABR (NP_001243776.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DPAA KENC MMHL LRSL PDPN LITF LFLL EHLK RVAE KEPI NKMS LHNL ATVF GPTL LRPS EVES KAHL TSAA DIWS HDVM AQVQ VLLY YLQH PPIS FAEL KRNT LYFS TDV
Gene ID:29
Uniprot:Q12979
Cellular Location:
Calculated MW:35kDa/92kDa/93kDa/97kDa
Observed MW:110kDa
Synonyms:ABR, MDB
Background:This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene.
UniProt Protein Function:ABR: GTPase-activating protein for RAC and CDC42. Promotes the exchange of RAC or CDC42-bound GDP by GTP, thereby activating them. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:GAPs, Rac/Rho; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); GAPs; ATYPICAL group; BCR family

Chromosomal Location of Human Ortholog: 17p13.3

Cellular Component: membrane; plasma membrane; cytosol

Molecular Function:Rho guanyl-nucleotide exchange factor activity; GTPase activator activity

Biological Process: inner ear morphogenesis; nerve growth factor receptor signaling pathway; positive regulation of apoptosis; response to lipopolysaccharide; negative regulation of neutrophil degranulation; regulation of small GTPase mediated signal transduction; positive regulation of phagocytosis; small GTPase mediated signal transduction; negative regulation of inflammatory response; brain development; actin cytoskeleton organization and biogenesis; neuromuscular process controlling balance; negative regulation of cell migration

Disease: Medulloblastoma

NCBI Summary:This gene encodes a protein that is similar to the protein encoded by the breakpoint cluster region gene located on chromosome 22. The protein encoded by this gene contains a GTPase-activating protein domain, a domain found in members of the Rho family of GTP-binding proteins. Functional studies in mice determined that this protein plays a role in vestibular morphogenesis. Alternatively spliced transcript variants have been reported for this gene. [provided by RefSeq, Feb 2012]
UniProt Code:Q12979
NCBI GenInfo Identifier:531034789
NCBI Gene ID:29
NCBI Accession:NP_001269078.1
UniProt Secondary Accession:Q12979,Q13693, Q13694, B3KW89, B7Z6H7, D3DTH3, D3DTH4 F5H3S2, F5H8B3,
UniProt Related Accession:Q12979
Molecular Weight:92,425 Da
NCBI Full Name:active breakpoint cluster region-related protein isoform e
NCBI Synonym Full Names:active BCR-related
NCBI Official Symbol:ABR  
NCBI Official Synonym Symbols:MDB  
NCBI Protein Information:active breakpoint cluster region-related protein
UniProt Protein Name:Active breakpoint cluster region-related protein
Protein Family:Active breakpoint cluster region-related protein
UniProt Gene Name:ABR  
UniProt Entry Name:ABR_HUMAN
Anti-ABR Antibody (CAB15635)Western blot analysis of extracts of various cell lines, using ABR antibody (CAB15635) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 120s.
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