Cell Biology Antibodies 6
Anti-ABO Antibody (CAB1586)
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- SKU:
- CAB1586
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ABO Antibody |
| Antibody SKU: | CAB1586 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 54-354 of human ABO (NP_065202.2). |
| Application: | WB IHC IF |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | K-562 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 54-354 of human ABO (NP_065202.2). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AVRE PDHL QRVS LPRM VYPQ PKVL TPCR KDVL VVTP WLAP IVWE GTFN IDIL NEQF RLQN TTIG LTVF AIKK YVAF LKLF LETA EKHF MVGH RVHY YVFT DQPA AVPR VTLG TGRQ LSVL EVRA YKRW QDVS MRRM EMIS DFCE RRFL SEVD YLVC VDVD MEFR DHVG VEIL TPLF GTLH PGFY GSSR EAFT YERR PQSQ AYIP KDEG DFYY LGGF FGGS VQEV QRLT RACH QAMM VDQA NGIE AVWH DESH LNKY LLRH KPTK VLSP EYLW DQQL LGWP AVLR KLRF TAVP KNHQ AVRN P |
| Gene ID: | 28 |
| Uniprot: | P16442 |
| Cellular Location: | Golgi apparatus, Golgi stack membrane, Secreted, Single-pass type II membrane protein |
| Calculated MW: | 40kDa |
| Observed MW: | 41kDa |
| Synonyms: | ABO, A3GALNT, A3GALT1, GTB, NAGAT |
| Background: | This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. |
| UniProt Protein Function: | ABO: This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity. Belongs to the glycosyltransferase 6 family. |
| UniProt Protein Details: | Protein type:Glycan Metabolism - glycosphingolipid biosynthesis - lacto and neolacto series; EC 2.4.1.37; Membrane protein, integral; EC 2.4.1.40; Transferase Chromosomal Location of Human Ortholog: 9q34.2 Cellular Component: integral to membrane; extracellular region Molecular Function:metal ion binding; glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity; fucosylgalactoside 3-alpha-galactosyltransferase activity Biological Process: protein amino acid glycosylation Disease: Blood Group, Abo System |
| NCBI Summary: | This gene encodes proteins related to the first discovered blood group system, ABO. Which allele is present in an individual determines the blood group. The 'O' blood group is caused by a deletion of guanine-258 near the N-terminus of the protein which results in a frameshift and translation of an almost entirely different protein. Individuals with the A, B, and AB alleles express glycosyltransferase activities that convert the H antigen into the A or B antigen. Other minor alleles have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P16442 |
| NCBI GenInfo Identifier: | 114949 |
| NCBI Gene ID: | 28 |
| NCBI Accession: | P16442.2 |
| UniProt Related Accession: | P16442 |
| Molecular Weight: | |
| NCBI Full Name: | Histo-blood group ABO system transferase |
| NCBI Synonym Full Names: | ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase |
| NCBI Official Symbol: | ABO |
| NCBI Official Synonym Symbols: | GTB; NAGAT; A3GALNT; A3GALT1 |
| NCBI Protein Information: | histo-blood group ABO system transferase |
| UniProt Protein Name: | Histo-blood group ABO system transferase |
| UniProt Synonym Protein Names: | Fucosylglycoprotein 3-alpha-galactosyltransferase; Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase; Glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase (EC:2.4.1.40); Glycoprotein-fucosylgalactoside alpha-galactosyltransferase (EC:2.4.1.37); Histo-blood group A transferase; A transferase; Histo-blood group B transferase; B transferase; NAGATFucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form |
| Protein Family: | 4-methylaminobutanoate oxidase |
| UniProt Gene Name: | ABO |
| UniProt Entry Name: | BGAT_HUMAN |
 | Western blot analysis of extracts of K-562 cells, using ABO antibody (CAB1586) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. |
 | Immunofluorescence analysis of MCF-7 cells using ABO antibody (CAB1586). Blue: DAPI for nuclear staining. |
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