Description
| Antibody Name: | Anti-ABI2 Antibody |
| Antibody SKU: | CAB14992 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | U-251MG, Mouse brain |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | HKEK VARR EIGI LTTN KNTS RTHK IIAP ANLE RPVR YIRK PIDY TILD DIGH GVKW LLRF KVST QNMK MGGL PRTT PPTQ KPPS PPMS GKGT LGRH SPYR T |
| Gene ID: | 10152 |
| Uniprot: | Q9NYB9 |
| Cellular Location: | Cell projection, Cytoplasm, cytoskeleton, filopodium, lamellipodium |
| Calculated MW: | 44kDa/52kDa/54kDa/55kDa |
| Observed MW: | 50kDa |
| Synonyms: | ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB |
| Background: |
| UniProt Protein Function: | Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 2q33 Cellular Component: cytoskeleton; lamellipodium; cytoplasm; cytosol; filopodium Molecular Function:protein binding; DNA binding; ubiquitin protein ligase binding; Rac GTPase binding; protein complex binding; cytoskeletal adaptor activity; kinase binding; SH3 domain binding Biological Process: cell migration; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; Rac protein signal transduction; cytoskeleton organization and biogenesis; cell motility |
| UniProt Code: | Q9NYB9 |
| NCBI GenInfo Identifier: | 50400673 |
| NCBI Gene ID: | 10152 |
| NCBI Accession: | Q9NYB9.1 |
| UniProt Related Accession: | Q9NYB9 |
| Molecular Weight: | 56 kDa |
| NCBI Full Name: | Abl interactor 2 |
| NCBI Synonym Full Names: | abl interactor 2 |
| NCBI Official Symbol: | ABI2 |
| NCBI Official Synonym Symbols: | AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB |
| NCBI Protein Information: | abl interactor 2 |
| UniProt Protein Name: | Abl interactor 2 |
| UniProt Synonym Protein Names: | Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1 |
| Protein Family: | Abl interactor |
| UniProt Gene Name: | ABI2 |
| UniProt Entry Name: | ABI2_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ABI2 antibody (CAB14992) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
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