Immunology Antibodies 1

Anti-ABI2 Antibody (CAB14992)

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SKU:
CAB14992
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-ABI2 Antibody
Antibody SKU:CAB14992
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human, Mouse
Positive Samples:U-251MG, Mouse brain
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 100-200 of human ABI2 (NP_001269854.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:HKEK VARR EIGI LTTN KNTS RTHK IIAP ANLE RPVR YIRK PIDY TILD DIGH GVKW LLRF KVST QNMK MGGL PRTT PPTQ KPPS PPMS GKGT LGRH SPYR T
Gene ID:10152
Uniprot:Q9NYB9
Cellular Location:Cell projection, Cytoplasm, cytoskeleton, filopodium, lamellipodium
Calculated MW:44kDa/52kDa/54kDa/55kDa
Observed MW:50kDa
Synonyms:ABI2, ABI-2, ABI2B, AIP-1, AblBP3, SSH3BP2, argBP1, argBPIA, argBPIB
Background:
UniProt Protein Function:Abi-2: May act in regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/or ABL2. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex. Regulates ABL1/c-Abl-mediated phosphorylation of MENA. Belongs to the ABI family. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Adaptor/scaffold; Motility/polarity/chemotaxis

Chromosomal Location of Human Ortholog: 2q33

Cellular Component: cytoskeleton; lamellipodium; cytoplasm; cytosol; filopodium

Molecular Function:protein binding; DNA binding; ubiquitin protein ligase binding; Rac GTPase binding; protein complex binding; cytoskeletal adaptor activity; kinase binding; SH3 domain binding

Biological Process: cell migration; peptidyl-tyrosine phosphorylation; actin polymerization and/or depolymerization; Rac protein signal transduction; cytoskeleton organization and biogenesis; cell motility

UniProt Code:Q9NYB9
NCBI GenInfo Identifier:50400673
NCBI Gene ID:10152
NCBI Accession:Q9NYB9.1
UniProt Related Accession:Q9NYB9
Molecular Weight:56 kDa
NCBI Full Name:Abl interactor 2
NCBI Synonym Full Names:abl interactor 2
NCBI Official Symbol:ABI2  
NCBI Official Synonym Symbols:AIP1; ABI-2; ABI2B; AIP-1; AblBP3; argBP1; SSH3BP2; argBPIA; argBPIB  
NCBI Protein Information:abl interactor 2
UniProt Protein Name:Abl interactor 2
UniProt Synonym Protein Names:Abelson interactor 2; Abi-2; Abl-binding protein 3; AblBP3; Arg-binding protein 1; ArgBP1
Protein Family:Abl interactor
UniProt Gene Name:ABI2  
UniProt Entry Name:ABI2_HUMAN
Anti-ABI2 Antibody (CAB14992)Western blot analysis of extracts of various cell lines, using ABI2 antibody (CAB14992) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s.
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