UniProt Protein Function: | ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family. |
UniProt Protein Details: | Chromosomal Location of Human Ortholog: 4q31 Cellular Component: mitochondrion; membrane; cytoplasm Molecular Function:ATPase activity; iron-sulfur cluster binding; ribonuclease inhibitor activity; ATP binding Biological Process: viral reproduction; response to virus; RNA catabolic process; negative regulation of catalytic activity |
NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61221 |
NCBI GenInfo Identifier: | 108773784 |
NCBI Gene ID: | 6059 |
NCBI Accession: | NP_001035809.1 |
UniProt Secondary Accession: | P61221,O88793, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10 Q99K66, |
UniProt Related Accession: | P61221 |
Molecular Weight: | Calculated: 67kDaObserved: 67kDa |
NCBI Full Name: | ATP-binding cassette sub-family E member 1 |
NCBI Synonym Full Names: | ATP-binding cassette, sub-family E (OABP), member 1 |
NCBI Official Symbol: | ABCE1 |
NCBI Official Synonym Symbols: | RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI |
NCBI Protein Information: | ATP-binding cassette sub-family E member 1 |
UniProt Protein Name: | ATP-binding cassette sub-family E member 1 |
UniProt Synonym Protein Names: | 2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I |
Protein Family: | ABC transporter E family |
UniProt Gene Name: | ABCE1 |
UniProt Entry Name: | ABCE1_HUMAN |