Immunology Antibodies 3

Anti-ABCE1 Antibody (CAB9135)

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SKU:
CAB9135
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Monoclonal Antibody
Research Area:
Immunology

Description

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Antibody Name:Anti-ABCE1 Antibody
Antibody SKU:CAB9135
Antibody Size:20uL, 50uL, 100uL
Application:WB IF
Reactivity:Human, Mouse
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human ABCE1
Application:WB IF
Recommended Dilution:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse
Positive Samples:HeLa, HT-29, K-562, Mouse liver, Mouse spleen, Mouse pancreas
Immunogen:A synthesized peptide derived from human ABCE1
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:6059
Uniprot:P61221
Cellular Location:
Calculated MW:67kDa
Observed MW:67KDa
Synonyms:ABC38, OABP, RLI, RLI1, RNASEL1, RNASELI, RNS4I
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Protein Function:ABCE1: Antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) by RNase L through direct interaction with RNase L and therefore inhibits its endoribonuclease activity. May play a central role in the regulation of mRNA turnover. Antagonizes the anti-viral effect of the interferon-regulated 2-5A/RNase L pathway. May act as a chaperone for post-translational events during HIV-1 capsid assembly. Belongs to the ABC transporter superfamily. ABCE family.
UniProt Protein Details:

Chromosomal Location of Human Ortholog: 4q31

Cellular Component: mitochondrion; membrane; cytoplasm

Molecular Function:ATPase activity; iron-sulfur cluster binding; ribonuclease inhibitor activity; ATP binding

Biological Process: viral reproduction; response to virus; RNA catabolic process; negative regulation of catalytic activity

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the OABP subfamily. Alternatively referred to as the RNase L inhibitor, this protein functions to block the activity of ribonuclease L. Activation of ribonuclease L leads to inhibition of protein synthesis in the 2-5A/RNase L system, the central pathway for viral interferon action. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P61221
NCBI GenInfo Identifier:108773784
NCBI Gene ID:6059
NCBI Accession:NP_001035809.1
UniProt Secondary Accession:P61221,O88793, Q13181, Q13864, Q6NR76, Q96AL0, Q96B10 Q99K66,
UniProt Related Accession:P61221
Molecular Weight:Calculated: 67kDaObserved: 67kDa
NCBI Full Name:ATP-binding cassette sub-family E member 1
NCBI Synonym Full Names:ATP-binding cassette, sub-family E (OABP), member 1
NCBI Official Symbol:ABCE1  
NCBI Official Synonym Symbols:RLI; OABP; ABC38; RNS4I; RNASEL1; RNASELI  
NCBI Protein Information:ATP-binding cassette sub-family E member 1
UniProt Protein Name:ATP-binding cassette sub-family E member 1
UniProt Synonym Protein Names:2'-5'-oligoadenylate-binding protein; HuHP68; RNase L inhibitor; Ribonuclease 4 inhibitor; RNS4I
Protein Family:ABC transporter E family
UniProt Gene Name:ABCE1  
UniProt Entry Name:ABCE1_HUMAN
Anti-ABCE1 Antibody (CAB9135)Western blot - ABCE1 Rabbit mAb (CAB9135)
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