Cell Biology Antibodies 13

Anti-ABCD4 Antibody (CAB17523)

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SKU:
CAB17523
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Cell Biology

Description

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Antibody Name:Anti-ABCD4 Antibody
Antibody SKU:CAB17523
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:MCF7
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:DQFT CNLL YVSW RKDL TEHL HRLY FRGR AYYT LNVL RDDI DNPD QRIS QDVE RFCR QLSS MASK LIIS PFTL VYYT YQCF QSTG WLGP VSIF GYFI LGTV VNKT LMGP IVMK LVHQ EKLE GDFR FKHM QIRV NAEP AAFY RAGH VEHM RTDR RLQR LLQT QREL MSKE LWLY IGIN TFDY L
Gene ID:5826
Uniprot:O14678
Cellular Location:
Calculated MW:
Observed MW:72kDa
Anti-ABCD4 Antibody (CAB17523)Western blot - ABCD4 Polyclonal Antibody (CAB17523)
Synonyms:ABC41, EST352188, MAHCJ, P70R, P79R, PMP69, PXMP1L, ABCD4
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]
UniProt Protein Function:ABCD4: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]
UniProt Protein Details:

Protein type:Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family

Chromosomal Location of Human Ortholog: 14q24.3

Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; lysosomal membrane; integral to membrane; peroxisome; ATP-binding cassette (ABC) transporter complex

Molecular Function:ATPase activity, coupled to transmembrane movement of substances; ATP binding

Biological Process: vitamin metabolic process; cobalamin metabolic process; transmembrane transport; water-soluble vitamin metabolic process

Disease: Methylmalonic Aciduria And Homocystinuria, Cblj Type

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008]
UniProt Code:O14678
NCBI GenInfo Identifier:4826958
NCBI Gene ID:5826
NCBI Accession:NP_005041.1
UniProt Secondary Accession:O14678,Q6IAQ0, Q96E75, A8K5L7,
UniProt Related Accession:O14678
Molecular Weight:68,597 Da
NCBI Full Name:ATP-binding cassette sub-family D member 4
NCBI Synonym Full Names:ATP-binding cassette, sub-family D (ALD), member 4
NCBI Official Symbol:ABCD4  
NCBI Official Synonym Symbols:P70R; P79R; ABC41; MAHCJ; PMP69; PXMP1L; EST352188  
NCBI Protein Information:ATP-binding cassette sub-family D member 4; PXMP1-L; PMP70-related protein; peroxisomal membrane protein 69; 69 kDa peroxisomal ABC-transporter
UniProt Protein Name:ATP-binding cassette sub-family D member 4
UniProt Synonym Protein Names:PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69; PMP69
Protein Family:ATP-binding cassette sub-family
UniProt Gene Name:ABCD4  
UniProt Entry Name:ABCD4_HUMAN
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