Signal Transduction Antibodies 2

Anti-ABCC5 Antibody (CAB3028)

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SKU:
CAB3028
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ABCC5 Antibody
Antibody SKU:CAB3028
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2).
Application:WB
Recommended Dilution:WB 1:1000 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:Mouse brain, Mouse lung, Rat brain
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-179 of human ABCC5 (NP_005679.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MKDI DIGK EYII PSPG YRSV RERT STSG THRD REDS KFRR TRPL ECQD ALET AARA EGLS LDAS MHSQ LRIL DEEH PKGK YHHG LSAL KPIR TTSK HQHP VDNA GLFS CMTF SWLS SLAR VAHK KGEL SMED VWSL SKHE SSDV NCRR LERL WQEE LNEV GPDA ASLR RVVW IFCR TRL
Gene ID:10057
Uniprot:O15440
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:23kDa/25kDa/155kDa/160kDa
Observed MW:185kDa
Synonyms:ABCC5, ABC33, EST277145, MOAT-C, MOATC, MRP5, SMRP, pABC11
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants.
UniProt Protein Function:ABCC5: Acts as a multispecific organic anion pump which can transport nucleotide analogs. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ABC family

Chromosomal Location of Human Ortholog: 3q27.1

Cellular Component: integral to plasma membrane; membrane; plasma membrane

Molecular Function:anion transmembrane-transporting ATPase activity; ATPase activity, coupled to transmembrane movement of substances; organic anion transmembrane transporter activity

Biological Process: hyaluronan biosynthetic process; transmembrane transport; transport

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions in the cellular export of its substrate, cyclic nucleotides. This export contributes to the degradation of phosphodiesterases and possibly an elimination pathway for cyclic nucleotides. Studies show that this protein provides resistance to thiopurine anticancer drugs, 6-mercatopurine and thioguanine, and the anti-HIV drug 9-(2-phosphonylmethoxyethyl)adenine. This protein may be involved in resistance to thiopurines in acute lymphoblastic leukemia and antiretroviral nucleoside analogs in HIV-infected patients. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
UniProt Code:O15440
NCBI GenInfo Identifier:8928547
NCBI Gene ID:10057
NCBI Accession:O15440.2
UniProt Secondary Accession:O15440,O14517, Q29ZA9, Q29ZB1, Q86UX3, Q86W30, Q9UN85 Q9UNP5, Q9UQC3, B9EIQ2,
UniProt Related Accession:O15440
Molecular Weight:161kDa
NCBI Full Name:Multidrug resistance-associated protein 5
NCBI Synonym Full Names:ATP binding cassette subfamily C member 5
NCBI Official Symbol:ABCC5  
NCBI Official Synonym Symbols:MRP5; SMRP; ABC33; MOATC; MOAT-C; pABC11; EST277145  
NCBI Protein Information:multidrug resistance-associated protein 5
UniProt Protein Name:Multidrug resistance-associated protein 5
UniProt Synonym Protein Names:ATP-binding cassette sub-family C member 5; Multi-specific organic anion transporter C; MOAT-C; SMRP; pABC11
Protein Family:ABC transporter C family
UniProt Gene Name:ABCC5  
Anti-ABCC5 Antibody (CAB3028)Western blot analysis of extracts of various cell lines, using ABCC5 antibody (CAB3028) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s.
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