Signal Transduction Antibodies 3

Anti-ABCC11 Antibody (CAB6514)

(No reviews yet) Write a Review
SKU:
CAB6514
Product Type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

system_update_altDatasheetsystem_update_altMSDS
Antibody Name:Anti-ABCC11 Antibody
Antibody SKU:CAB6514
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ABCC11 (NP_660187.1).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:Raji, HT-29
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 1-170 of human ABCC11 (NP_660187.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:MTRK RTYW VPNS SGGL VNRG IDIG DDMV SGLI YKTY TLQD GPWS QQER NPEA PGRA AVPP WGKY DAAL RTMI PFRP KPRF PAPQ PLDN AGLF SYLT VSWL TPLM IQSL RSRL DENT IPPL SVHD ASDK NVQR LHRL WEEE VSRR GIEK ASVL LVML RFQR TRLI FDAL LG
Gene ID:85320
Uniprot:Q96J66
Cellular Location:Membrane, Multi-pass membrane protein
Calculated MW:150kDa/154kDa
Observed MW:128kDa
Synonyms:ABCC11, EWWD, MRP8, WW
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene.
UniProt Protein Function:ABCC11: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax. Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Transporter; Membrane protein, integral; Transporter, ABC family

Chromosomal Location of Human Ortholog: 16q12.1

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function:anion transmembrane-transporting ATPase activity; organic anion transmembrane transporter activity; purine nucleotide transmembrane transporter activity

Biological Process: organic anion transport; purine nucleotide transport; transmembrane transport

Disease: Apocrine Gland Secretion, Variation In

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This ABC full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a SNP in this gene is responsible for determination of human earwax type. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12.1. Multiple alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:Q96J66
NCBI GenInfo Identifier:74762666
NCBI Gene ID:85320
NCBI Accession:Q96J66.1
UniProt Secondary Accession:Q96J66,Q8TDJ0, Q96JA6, Q9BX80,
UniProt Related Accession:Q96J66
Molecular Weight:150,093 Da
NCBI Full Name:ATP-binding cassette sub-family C member 11
NCBI Synonym Full Names:ATP binding cassette subfamily C member 11
NCBI Official Symbol:ABCC11  
NCBI Official Synonym Symbols:WW; EWWD; MRP8  
NCBI Protein Information:ATP-binding cassette sub-family C member 11
UniProt Protein Name:ATP-binding cassette sub-family C member 11
UniProt Synonym Protein Names:Multidrug resistance-associated protein 8
Protein Family:ABC transporter C family
UniProt Gene Name:ABCC11  
UniProt Entry Name:ABCCB_HUMAN
Anti-ABCC11 Antibody (CAB6514)Western blot analysis of extracts of various cell lines, using ABCC11 antibody (CAB6514) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 120s.
View AllClose

0 Reviews

View AllClose

Related Products