Signal Transduction Antibodies 1

Anti-ABCC1 Antibody (CAB11153)

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SKU:
CAB11153
Product Type:
Antibody
Reactivity:
Human
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Signal Transduction

Description

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Antibody Name:Anti-ABCC1 Antibody
Antibody SKU:CAB11153
Antibody Size:20uL, 50uL, 100uL
Application:WB IHC
Reactivity:Human, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-960 of human ABCC1 (NP_004987.2).
Application:WB IHC
Recommended Dilution:WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:Human, Rat
Positive Samples:HepG2, HeLa
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 850-960 of human ABCC1 (NP_004987.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:GSYQ ELLA RDGA FAEF LRTY ASTE QEQD AEEN GVTG VSGP GKEA KQME NGML VTDS AGKQ LQRQ LSSS SSYS GDIS RHHN STAE LQKA EAKK EETW KLME ADKA QTGQ VKL
Gene ID:4363
Uniprot:P33527
Cellular Location:Cell membrane, Multi-pass membrane protein
Calculated MW:151-172kDa
Observed MW:210kDa
Synonyms:ABCC1, ABC29, ABCC, GS-X, MRP, MRP1
Background:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown.
UniProt Protein Function:ABCC1: a multi-pass membrane protein. A multidrug resistance member of the ABC transporter family that confers resistance to anticancer drugs. A multi-pass membrane protein. Exports sphingosine-1-phosphate (S1P), a potent inflammatory mediator, from mast cells during mast cell-mediated immune responses. Nine alternatively spliced human isoforms have been reported.
UniProt Protein Details:

Protein type:Membrane protein, multi-pass; Membrane protein, integral; Transporter, ABC family; Transporter

Chromosomal Location of Human Ortholog: 16p13.1

Cellular Component: membrane; integral to plasma membrane; plasma membrane

Molecular Function:ATPase activity, coupled to transmembrane movement of substances; transporter activity; ATPase activity; ATP binding

Biological Process: response to drug; vitamin metabolic process; transport; cobalamin metabolic process; arachidonic acid metabolic process; leukotriene metabolic process; transmembrane transport; water-soluble vitamin metabolic process

NCBI Summary:The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra-and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This full transporter is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutatione, cysteinyl leukotrienes, and activated aflatoxin B1 as substrates. This protein also transports glucuronides and sulfate conjugates of steroid hormones and bile salts. Alternatively spliced variants of this gene have been described but their full-length nature is unknown. [provided by RefSeq, Apr 2012]
UniProt Code:P33527
NCBI GenInfo Identifier:296439301
NCBI Gene ID:4363
NCBI Accession:P33527.3
UniProt Secondary Accession:P33527,O14819, O43333, P78419, Q59GI9, Q9UQ97, Q9UQ99 Q9UQA0, A3RJX2, C9JPJ4,
UniProt Related Accession:P33527
Molecular Weight:1531
NCBI Full Name:Multidrug resistance-associated protein 1
NCBI Synonym Full Names:ATP-binding cassette, sub-family C (CFTR/MRP), member 1
NCBI Official Symbol:ABCC1  
NCBI Official Synonym Symbols:MRP; ABCC; GS-X; MRP1; ABC29  
NCBI Protein Information:multidrug resistance-associated protein 1; LTC4 transporter; leukotriene C(4) transporter; ATP-binding cassette transporter variant ABCC1delta-ex13; ATP-binding cassette transporter variant ABCC1delta-ex25; ATP-binding cassette transporter variant ABCC1de
UniProt Protein Name:Multidrug resistance-associated protein 1
UniProt Synonym Protein Names:ATP-binding cassette sub-family C member 1; Leukotriene C(4) transporter; LTC4 transporter
Protein Family:37S ribosomal protein
UniProt Gene Name:ABCC1  
UniProt Entry Name:MRP1_HUMAN
Anti-ABCC1 Antibody (CAB11153)Western blot analysis of extracts of HepG2 cells, using ABCC1 antibody (CAB11153) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s.
Anti-ABCC1 Antibody (CAB11153)Western blot analysis of extracts of HeLa cells, using ABCC1 antibody (CAB11153) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 10s.
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