Cell Biology Antibodies 15
Anti-ABCB5 Antibody (CAB17882)
- SKU:
- CAB17882
- Product Type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
| Antibody Name: | Anti-ABCB5 Antibody |
| Antibody SKU: | CAB17882 |
| Antibody Size: | 20uL, 50 uL |
| Application: | IF |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-230 of human ABCB5 (NP_848654.3). |
| Application: | IF |
| Recommended Dilution: | IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 120-230 of human ABCB5 (NP_848654.3). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | AALE KASK GRTT IVVA HRLS TIRS ADLI VTLK DGML AEKG AHAE LMAK RGLY YSLV MSQD IKKA DEQM ESMT YSTE RKTN SLPL HSVK SIKS DFID KAEE STQS KEIS LPE |
| Gene ID: | 340273 |
| Uniprot: | Q2M3G0 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | Refer to figures |
| Synonyms: | ABCB5alpha, ABCB5beta, EST422562, ABCB5 |
| Background: | ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008] |
| UniProt Protein Function: | ABCB5: Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas. Belongs to the ABC transporter superfamily. ABCB family. Multidrug resistance exporter (TC 3.A.1.201) subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transporter, ABC family; Transporter; Membrane protein, integral; Membrane protein, multi-pass Chromosomal Location of Human Ortholog: 7p21.1 Cellular Component: integral to plasma membrane; plasma membrane Molecular Function:ATP binding; ATPase activity, coupled to transmembrane movement of substances; efflux transmembrane transporter activity Biological Process: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; cell differentiation; compound eye corneal lens development; metabolic process; positive regulation of antigen processing and presentation of peptide antigen via MHC class I; regulation of membrane potential; transmembrane transport |
| NCBI Summary: | ABCB5 belongs to the ATP-binding cassette (ABC) transporter superfamily of integral membrane proteins. These proteins participate in ATP-dependent transmembrane transport of structurally diverse molecules ranging from small ions, sugars, and peptides to more complex organic molecules (Chen et al., 2005 [PubMed 15760339]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q2M3G0 |
| NCBI GenInfo Identifier: | 693586060 |
| NCBI Gene ID: | 340273 |
| NCBI Accession: | Q2M3G0.4 |
| UniProt Secondary Accession: | Q2M3G0,Q2M3I5, Q5I5Q7, Q5I5Q8, Q6KG50, A4D131, A7BKA4 B5MD19, B7WPL1, F8QQP8, F8QQP9, J3KQ04, |
| UniProt Related Accession: | Q2M3G0 |
| Molecular Weight: | 89,832 Da |
| NCBI Full Name: | ATP-binding cassette sub-family B member 5 |
| NCBI Synonym Full Names: | ATP binding cassette subfamily B member 5 |
| NCBI Official Symbol: | ABCB5 |
| NCBI Official Synonym Symbols: | ABCB5beta; EST422562; ABCB5alpha |
| NCBI Protein Information: | ATP-binding cassette sub-family B member 5 |
| UniProt Protein Name: | ATP-binding cassette sub-family B member 5 |
| UniProt Synonym Protein Names: | ABCB5 P-gp; P-glycoprotein ABCB5 |
| Protein Family: | ABC transporter B family |
| UniProt Gene Name: | ABCB5 |
| UniProt Entry Name: | ABCB5_HUMAN |
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